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在接受了对抗药物耐药性的thalamic响应神经刺激治疗的儿科患者群体中,中心中间核向

Marian Michael Bercu¹, Bahram Sarvi Zargar², Kathryn E Spykman²

¹Division of Pediatric Neurosurgery, Helen DeVos Children's Hospital, Corewell Health, Grand Rapids, Michigan, USA.

|November 13, 2025

概括

针对中心中核 (CMN) 的响应性神经刺激 (RNS) 有效地减少了儿科耐药性 (DRE) 的发作. 这种安全的方法在83.3%的患者中减少了80.4%的发作.

科学领域:

神经学神经学
神经外科神经外科
发病学 (Epileptology) 是一个专业的学科.

背景情况:

儿科患者的耐药性 (DRE) 存在重大管理挑战.
脑膜中枢核 (CMN) 的神经刺激是一种潜在的治疗策略.
响应神经刺激 (RNS) 为控制提供了一个有针对性的方法.

研究的目的:

评估针对儿童DRE的CMN的RNS的疗效和安全性.
评估与结果相关的发作减少率和接触位置.
报告小儿病患者病例系列的初步结果.

主要方法:

有DRE的13名儿科患者接受了直接向CMN的RNS.
用磁化准备的2个快速梯度回声 (MP2RAGE) 扫描和ClearPoint神经导航用于精确的电极放置.
手术后成像和概率解剖模型 (Freesurfer) 证实了CMN内的接触定位.

主要成果:

12名多焦点或泛性DRE患者中有10名 (83.3%) 实现了超过50%的发作减少.
在接受治疗的队列中,平均发作减少率为80.4%.
在平均252个月的随访期间,没有报告刺激相关的副作用;95.8%的电极具有准确的CMN接触.

结论:

使用RNS对CMN的高精度直接准显示出在儿科DRE中强大的疗效.
这种神经刺激方法对于管理具有挑战性的儿科病例是安全有效的.
精确的电极放置对于CMN向RNS的成功结果至关重要.

关键词:

泰拉马斯的中心中核核.直接准是直接的准.药物耐药性 - 抗药性儿科儿科儿科响应神经刺激的反应性神经刺激.

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