类在骨肌肉消耗中的作用:一个范围广泛的综述
Petar Naumovski1,2, Bart De Spiegeleer1,2, Aster Wakjira1,3,4
1Translational Research in Immunosenescence, Gerontology and Geriatrics (TRIGG) Group, Ghent University Hospital, Ghent, Belgium.
Journal of cachexia, sarcopenia and muscle
|November 13, 2025
概括
可以作为生物标志物和治疗肌肉消耗的治疗标. 需要进一步的研究来解决研究的局限性,并改善这些生物活性分子的临床转化.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 老年学是一门学科.
背景情况:
- 系统性肌肉消耗是衰老和疾病中的一个重要健康问题,预测生物标志物和治疗方法有限.
- 由于它们在肌肉健康中的多样化的生物活性功能,类正在成为潜在的生物标志物和治疗剂.
研究的目的:
- 系统地审查和确定关于和肌肉衰竭的临床方面之间的关联的研究.
- 合成有关细胞通路的信息,将与肌肉平衡和衰减联系起来.
主要方法:
- 根据PRISMA-ScR指南进行范围审查,搜索Embase,PubMed和Web of Science,直到2024年10月.
- 包括原始的人类和动物研究,不包括特定的肌肉疾病和神经退行性疾病.
- 雪球方法用于合成已识别的的细胞通路.
主要成果:
- 126项研究确定了87种与肌肉消耗相关的独特,包括格林素,BNP,C-,胰岛素和SS-31.
- 大多数会影响关键的肌肉平衡途径 (例如PI3K/Akt/mTOR,AMPK/PGC1α),调节缩和高缩.
- 在研究设计,报告 (例如,性别偏见,预分析差距) 和临床翻译方面注意到了显著的局限性.
结论:
- 类具有作为生物标志物和肌肉消耗条件的治疗标的巨大潜力.
- 解决研究设计缺陷,改善人口代表性和标准化报告对于临床翻译至关重要.
- 机器学习可能有助于发现用于肌肉消耗干预的新型生物活性.
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