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25(OH) D改变了糖尿病患者抑郁症状和慢性病之间的关系

Ying Yang¹, Qian Wang¹, Xiyu Ge¹

¹The First Clinical Medical College, Nanjing University of Chinese Medicine, 157 Hanzhong Road, Nanjing, 210029, People's Republic of China.

International urology and nephrology

|November 13, 2025

概括

较高的25-氧维生素D (25(OH) D水平改变了糖尿病患者中抑郁症状和慢性病 (CKD) 之间的联系. 在这个人群中,较高的25~OH) D度可能会否定抑郁症和CKD之间的关联.

科学领域:

内分泌学在内分泌学.
腎臟病學 (nephrology) 是一種醫學.
精神病学是一个精神病学.

背景情况:

25-氧维生素D (25(OH) D) 与抑郁症状和慢性病 (CKD) 有关,特别是在糖尿病患者中.
对于25(OH) D水平对糖尿病中抑郁症和CKD之间的关联的潜在改变作用仍然不清楚.

研究的目的:

调查25-氧维生素D (25(OH) D的高水平是否会改变糖尿病患者抑郁症状和慢性病 (CKD) 之间的关联.
确定影响这种关系的25...OH) D度的值.

主要方法:

使用国家健康和营养检查调查 (2007-2018) 数据进行的横截面研究.
包括5196名糖尿病患者,通过PHQ-9评估抑郁症状,并以中位数 (56.1nmol/L) 分层25(OH) D.
使用加权后勤回归和相互作用分析 (包括约翰逊-尼曼) 来检查25(OH) D. 的修饰作用.

主要成果:

抑郁症状 (PHQ-9分数≥10) 是CKD的一个独立风险因素 (OR=1.31).
抑郁症状和CKD之间的关联在25(OH) D ≤56.1nmol/L (OR=1.65) 时是显著的,但在25(OH) D>56.1nmol/L (OR=1.00) 时不是显著的.
发现了显著的相互作用,表明高的25(OH) D改变了抑郁症和CKD相关性 (P=0.039),其修改度为58.7nmol/L.

结论:

在糖尿病患者中,高水平的25-氧维生素D (25(OH) D显著改变了抑郁症状和慢性病 (CKD) 之间的关系.
这些发现表明,较高的维生素D水平对这种人群中抑郁症对脏健康的不利影响有潜在的保护作用.

关键词:

25 (((OH) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D) D)在CKD中,它是最好的.抑郁症的症状抑郁症的症状糖尿病患者糖尿病患者

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