阻塞性睡眠呼吸暂停与复发性肺栓塞之间的关联:一个元分析
1Department of Pulmonary Diseases, the , Third Affiliated Hospital of Changchun University of Chinese Medicine, Changchun Jingyue High-Tech Industry Development Zone, No. 1643, Changchun, 130117, China.
Irish journal of medical science
|November 13, 2025
概括
阻塞性睡眠呼吸暂停 (OSA) 与复发性肺栓塞 (PE) 的风险增加近两倍. 在PE患者中查OSA可能会提高风险评估和预防策略.
科学领域:
- 肺部医学 肺部医学
- 睡眠医学 睡眠医学
- 心血管研究研究心血管研究
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 被怀疑有助于原血栓和炎症状态.
- 这些状态可能会增加患病患者复发性肺栓塞 (PE) 的风险.
- 然而,OSA和复发性PE风险之间的明确联系尚未确定.
研究的目的:
- 系统地评估阻塞性睡眠呼吸暂停 (OSA) 与复发性肺栓塞 (PE) 风险之间的关联.
- 综合纵向观测研究的证据来量化这种关联.
主要方法:
- 在主要数据库 (PubMed,Embase,Web of Science,Wanfang,CNKI) 进行了系统的文献搜索.
- 包括调查OSA和复发性PE的长度观察性研究.
- 使用随机效应模型计算了95%置信区间 (CI) 的聚合风险比率 (RRs).
主要成果:
- 分析了包括6262名PE患者在内的8项研究,其中10.7%被诊断为OSA.
- 患有OSA的患者表现出明显更高的复发性PE风险 (RR,2.46;95% CI,1.46至4.12).
- 这种关联在研究设计中是强大的,在较小的队列中更强,样本大小可能解释异质性.
结论:
- 阻塞性睡眠呼吸暂停 (OSA) 与复发性肺栓塞 (PE) 的风险增加有关.
- 在大规模的前性研究中需要进一步验证.
- 在PE患者中查OSA可能会改善风险分层和二次预防工作.
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