多民族队列研究中的饮食模式和前列腺癌风险
Wei Xiong1, Song-Yi Park2, Peggy Wan1
1University of Southern California, Los Angeles, CA, United States.
概括
饮食模式在不同种族群体中显示出与前列腺癌 (PCa) 风险的不同关联. 像DASH这样的特定饮食可能会降低非裔美国人的高级PCa风险,而其他饮食可能会增加日裔美国人的低级PCa风险.
科学领域:
- 营养流行病学 营养流行病学
- 癌症研究 癌症研究
- 公共卫生 公共卫生
背景情况:
- 健康饮食与降低癌症风险有关,但其对前列腺癌 (PCa) 的影响尚不清楚,特别是在多样化的人口中.
- 前列腺癌风险因素和预防策略需要进一步调查.
研究的目的:
- 为了检查11种饮食模式与前列腺癌风险在多民族队列中的关联.
- 调查这些关联是否因种族/种族和瘤特征而有所不同.
主要方法:
- 多民族队列研究包括来自不同种族/种族背景的79,930名男性.
- 考克斯的比例危险模型评估了11个饮食得分和PCa风险之间的关联.
- 分析按种族/种族分层,并根据多次测试进行调整 (p<0.003).
主要成果:
- 在一般人群中,饮食得分和PCa风险之间没有总体关联.
- 更高的饮食方法阻止高血压 (DASH) 评分与非洲裔美国人的晚期PCa风险降低有关 (HR=0.86,p=0.02).
- 较高的胰岛素抵抗实证饮食指数 (EDIR) 分数与日裔美国人的低级/非侵略性PCa风险增加有关 (HRs ≈ 1.09-1.10, p≈0.01-0.02).
结论:
- 特定的饮食模式可能会影响PCa风险在种族/族群和瘤亚型之间有所不同.
- 研究结果表明,对于预防PCa而言,需要以文化为基础的饮食建议.
- 需要对大量多样化的群体进行进一步的研究来证实这些关联.
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