scMOVIR:人类病毒感染和免疫反应的单细胞多omics数据库
Xue Zhang1,2, Shounan Yang1, Xiaobin Xu1,2
1State Key Laboratory of Advanced Drug Delivery and Release Systems & Innovation Institute for Artificial Intelligence in Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Nucleic acids research
|November 13, 2025
概括
scMOVIR 是一个新的数据库,集成单细胞多组数据用于病毒感染. 它为研究病毒与宿主免疫相互作用和推进抗病毒研究提供了全面的资源.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 生物信息学是一种生物信息学.
背景情况:
- 病毒感染是一个重大的全球健康挑战,需要先进的工具来理解复杂的宿主免疫反应.
- 单细胞多组技术为剖析病毒感染期间细胞异质性和免疫动态提供了前所未有的分辨率.
- 现有的资源缺乏专门针对人类病毒感染的单细胞多组数据的全面整合.
研究的目的:
- 推出scMOVIR,一个新的,集成的单细胞多omics数据库,用于人类病毒感染和免疫反应.
- 为探索病毒与宿主相互作用并促进抗病毒研究提供高分辨率的参考资料.
- 为了使细胞异质性,转录性变化和免疫受体谱的系统分析.
主要方法:
- 在单细胞分辨率下系统地整合转录基因,蛋白质基因和免疫受体谱系数据.
- 汇编了8532个人类样本,涵盖了114个病毒实体和59个疾病状态,覆盖了30多种组织类型.
- 标准化数据预处理,包括批次校正,统一的单元类型注释和使用本体学进行元数据协调.
主要成果:
- scMOVIR集成了来自各种病毒感染,疾病状态和实验条件 (疫苗接种,治疗方法,时间流程) 的数据.
- 该数据库提供了用户友好的界面,用于探索和互动可视化细胞动态和分子配置文件.
- 为研究复杂的病毒与宿主免疫相互作用提供了统一和一致的资源.
结论:
- scMOVIR是科学界研究病毒感染和免疫力的宝贵高分辨率资源.
- 该数据库有助于更深入地了解抗病毒免疫力,并支持开发新型治疗策略.
- 能够对广泛的病毒性疾病的细胞异质性和免疫反应进行全面的调查.
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