对于克罗恩病的生物标志物指导疗法的最新发展
André Bargas1, Joana Torres1,2,3, Bram Verstockt4,5
1Division of Gastroenterology, Surgical Department, Hospital Beatriz Ângelo, Loures, Portugal.
生物标志物对于在克罗恩病 (CD) 中推进精准医学至关重要. 目前的研究审查了血清学,遗传学和其他标记,强调需要克服实施障碍,以获得更好的CD患者护理.
科学领域:
- 胃肠道学和免疫学
- 翻译医学是一种翻译医学.
- 生物标志物发现发现
背景情况:
- 克罗恩氏病 (CD) 是一种慢性炎症状况,其进展和治疗反应不可预测.
- 扩大的治疗选择需要可靠的生物标志物用于诊断,风险分层和治疗指导.
- 目前对CD的管理往往缺乏经过验证的生物标志物所提供的精度.
研究的目的:
- 审查当前生物标志物开发和克罗恩病应用的现状.
- 在不同疾病阶段批判性地评估各种类型的生物标志物 (血清学,遗传学,转录学,蛋白质学,表观遗传学).
- 确定限制和障碍,阻碍CD.生物标志物的临床实施.
主要方法:
- 关于克罗恩病生物标志物研究的综合文献综述.
- 对不同类别的生物标志物的证据进行批判性评估.
- 分析临床翻译和实施中的挑战.
主要成果:
- 在多个"omic"平台上的生物标志物发现方面取得了重大进展.
- 存在血清学,遗传学,转录学,蛋白质学和表观遗传学标记的证据,但需要进一步验证.
- 临床实施仍存在重大障碍,包括成本,标准化和监管问题.
结论:
- 目前,CD中的精准医学由于缺乏经过验证,可部署的生物标志物而受到限制.
- 从发现生物标志物的转变到实施是必不可少的,将它们纳入临床试验和实践.
- 克服生物标志物验证和采用障碍对于改善克罗恩病管理至关重要.
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