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Updated: Jan 11, 2026

Assay to Measure Nucleocytoplasmic Transport in Real Time within Motor Neuron-like NSC-34 Cells
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马克2调节C9orf72重复关联的非AUG翻译

Yu-Ning Lu1, Xiangning Li1, Lindsey Hayes2

  • 1Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205.

Proceedings of the National Academy of Sciences of the United States of America
|November 13, 2025
PubMed
概括

微管类亲和调节酶2 (MARK2) 增强了重复关联的非AUG (RAN) 转化,产生与神经退行性疾病 (如C9-ALS/FTD) 相关的有毒蛋白质. 抑制MARK2可以提供神经保护,防止这种毒性.

关键词:
马克2是什么意思如果 eIF2α综合应激反应综合应激反应

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