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Updated: Jan 11, 2026

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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Published on: March 27, 2020

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循环节调节器REV-ERBα是瘤谱系可塑性的主调节器,也是有效的治疗点

Xiong Zhang1, Yatian Yang1, Hongye Zou1

  • 1Department of Biochemistry and Molecular Medicine, School of Medicine, University of California Davis, Davis, CA 95817.

Proceedings of the National Academy of Sciences of the United States of America
|November 13, 2025
PubMed
概括

雄激素受体信号传递抑制剂重编程REV-ERBα,驱动前列腺癌谱系可塑性和神经内分泌前列腺癌 (NEPC) 进展. 抑制REV-ERBα有效地阻断NEPC生长,提供了一个有前途的治疗标.

关键词:
美国国家电力公司 (NEPC)这就是REV-ERBα.药物耐药性 耐药性 药物耐药性血统的可塑性 血统的可塑性治疗向的治疗向

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