认知功能与身体表现之间的双向和值反应关联的评估:全国跨部门研究
Huixiu Hu1, Lanying Xie2, Yuqing Hao3
1Department of Nursing, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Science, Beijing Hospital, 1 Da Hua Road, DongDan, Dongcheng District, Beijing, 100730, China, 86 85138512.
JMIR public health and surveillance
|November 13, 2025
概括
认知障碍对老年人的身体功能有很大影响,在19-24的迷你精神状态检查 (MMSE) 评分之间确定了一个关键的干预窗口. 特定的子组表现出更大的脆弱性.
科学领域:
- 老年学是一门学科.
- 神经科学是一个神经科学.
- 公共卫生 公共卫生
背景情况:
- 全球人口老龄化面临认知和身体衰退的风险增加.
- 老年人认知和身体健康之间的复杂,非线性关系尚未得到充分理解.
研究的目的:
- 调查老年人认知功能和身体表现之间的双向和非线性关联.
- 为了确定值效应和特定的子组在下降的风险更高.
主要方法:
- 一项多中心研究分析了中国的20868名老年人.
- 使用逻辑/线性回归和受限立方线来检查不对称和值-响应关联.
- 进行子组和相互作用分析以确定脆弱人群.
主要成果:
- 揭示了一个不对称的双向关系,认知障碍更强烈地影响身体功能 (SPPB,步行速度).
- 在迷你精神状态考试 (MMSE) 得分 (19,24,29) 中确定了关键的拐点,在MMSE 24以下的身体表现有显著的保护.
- 在高收入和高学历的子群体中发现了更高的脆弱性,这对MMSE得分更高的步行速度产生了矛盾的影响.
结论:
- 证明了老年人认知和身体表现之间的双向,不对称的关系.
- 强调存在非线性值效应和显著的人口异质性.
- 建议基于认知状态值的有针对性的干预措施,以改善身体健康结果.
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