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COVID-19疫苗接种和流产风险:在母胎界面进行RNA-seq和生物信息学分析

Yiyuan Qu¹, Chengcheng Zhu¹, Tao Sun¹

¹Department of Obstetrics-Gynecology, Center for Reproduction, the Fourth Affiliated Hospital, International Institutes of Medicine, Zhejiang University School of Medicine, Yiwu, Zhejiang, China.

Journal of global health

|November 13, 2025

概括

COVID-19疫苗似乎没有增加流产风险. 在母胎界面的基因表达分析表明,疫苗积极影响免疫耐受性,与感染不同.

科学领域:

免疫学免疫学免疫学
基因组学就是基因组学.
生殖医学生殖医学

背景情况:

由于对母胎界面 (MFI) 安全性的数据有限,怀孕期间对COVID-19疫苗的犹仍然存在.
COVID-19疫苗和流产之间的潜在联系需要进一步调查.

研究的目的:

调查COVID-19疫苗是否会改变MFI的基因表达.
为了确定疫苗对反复流产风险的影响.

主要方法:

接种疫苗和未接种疫苗的孕妇组织的RNA测序.
对公开可用的数据集的生物信息分析 (GSE181238,GSE22490) 专注于MFI基因表达,功能和分布.

主要成果:

在接种疫苗的组中发现了879个差异表达的基因,具有上调的补体激活和细胞粘附途径.
该疫苗抑制了在重复流产中过度表达的基因,包括FOS,FOSB和LY96.
观察到疫苗诱导的免疫活性,类似于但比感染弱,抑制流产相关途径和促进免疫耐受性.

结论:

COVID-19疫苗似乎对母胎免疫微环境产生了非负面影响.
该研究表明,COVID-19疫苗不太可能增加流产的风险.

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