氧化平衡得分和高血压患者的全因死亡率
Lian-Zhen Huang1, Hong-Bin Zhang2, Mei Qin1
1Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Journal of global health
|November 13, 2025
概括
保持较高的氧化平衡得分 (OBS) 与高血压患者的死亡风险降低有关. 这表明,健康的生活方式和富含抗氧化剂的饮食可以显著降低这一群体的死亡率.
科学领域:
- 心血管健康 心血管健康
- 营养流行病学 营养流行病学
- 氧化压力研究研究 氧化压力研究
背景情况:
- 氧化应激是已知的高血压及其相关健康并发症的贡献者.
- 氧化平衡评分 (OBS) 为评估氧化平衡对健康结果的影响提供了一个潜在的指标.
- 调查OBS与高血压患者死亡率之间的联系对于公共卫生至关重要.
研究的目的:
- 检查氧化平衡评分 (OBS) 与大量高血压个体的全因死亡率之间的关联.
- 确定导致OBS的饮食和生活方式因素是否会影响死亡风险.
- 探索OBS和死亡风险之间的剂量反应关系.
主要方法:
- 利用了来自国家健康和营养检查调查 (2007-2018) 的数据,其中包括11,196名高血压参与者.
- 根据饮食和生活方式因素计算OBS,将参与者分为四分之一.
- 采用了考克斯的比例危险模型,受限立方线分析和卡普兰-梅尔生存曲线来分析死亡率关联.
主要成果:
- 较高的OBS与较低的全因死亡风险显著相关 (最高四分位数的HR=0.66).
- 每增加一单位的OBS与2%的死亡风险降低相关 (HR=0.98).
- 通过生存分析观察到几乎线性剂量-反应关系,并通过生存分析证实了更高OBS的更好的生存率.
结论:
- 增加的OBS,包括其饮食和生活方式成分,与高血压患者全因死亡率的降低有显著联系.
- 研究结果强调了氧化平衡,富含抗氧化剂的饮食和健康的生活方式对于减轻死亡风险的重要性.
- 这项研究提供了支持生活方式干预措施的证据,以改善高血压人口的结果.
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