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聚焦超声波暴露参数和微泡度对化剂量的影响

Katarzyna Sendek¹, Ryszard Tymkiewicz¹, Lukasz Fura¹

¹Institute of Fundamental Technological Research, Polish Academy of Sciences, Pawińskiego 5B, Warsaw, 02-106, Poland.

Biomedical physics & engineering express

|November 13, 2025

概括

使用微气泡 (MB) 的聚焦超声波 (FUS) 可以打开血脑屏障 (BBB). 这项研究揭示了脉冲数,而不仅仅是脉冲长度,是控制化剂量的关键,以获得更安全,更有效的FUS治疗.

科学领域:

生物医学工程生物医学工程
声学声学在声学方面
药理学药理学是指药理学的学科.

背景情况:

聚焦超声波 (FUS) 与微气泡 (MBs) 是一种用于局部治疗效果的技术,例如打开血脑屏障 (BBB).
MB的声学排放表明化活动,这对于评估FUS治疗的有效性和安全性至关重要.
在FUS过程中控制空腔剂量的最佳参数仍然不完全理解.

研究的目的:

为了研究微气泡度,负压峰值,脉冲持续时间和有效超声波时间对化活动的影响.
量化空洞化剂量,包括稳定的波 (SCDhar),超波 (SCDultra) 和惯性空洞化 (ICD) 排放.
探索脉冲数和化剂量动态之间的关系.

主要方法:

使用流量设置,在不同的FUS参数下检查化活动.
微气泡度在0.00080.4%V/V.之间.
测试的峰值负压力为61.52600 kPa,脉冲持续时间为95952 μs.

主要成果:

稳定波 (SCDhar) 和惯性空心剂量 (ICD) 通常随着压力和MB度的增加而增加.
超波化剂量 (SCDultra) 在中间参数值时达到峰值.
随着脉冲数的增加,随着时间的推移显著改变了洞腔剂量,独立于有效的超声波时间,观察到10%的可重复性.

结论:

脉冲数是一个关键的,未被认可的参数,影响FUS治疗中的微气泡动态和空洞化剂量.
研究结果提供了对优化FUS协议的见解,以提高血脑屏障开放的安全性,一致性和有效性.
这项研究有助于改进基于超声波的治疗策略.

关键词:

洞化剂量是指空洞化剂量.这些微小气泡是微型气泡.不线性振荡的非线性振荡.超声波超声波是指超声波的使用.

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