相关实验视频

Updated: Jan 11, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

预防性抗生素免疫抑制个体与前鼻包装:一个倾向性得分匹配分析

Quincy K Tran¹, Melissa K Rallo², Isha Vashee³

¹Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD, United States; Research Associate Program in Emergency Medicine & Critical Care, Department of Emergency Medicine, University of Maryland School of Medicine, Baltimore, MD, United States; Program In Trauma, The R Adam Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD, United States.

The American journal of emergency medicine

|November 13, 2025

概括

预防性抗生素对接受前鼻包装 (ANP) 进行表术的免疫抑制患者没有好处,表现出类似的临床重要感染 (CSI) 和更高的不良药物反应率. 抗生素管理对这一群体至关重要.

科学领域:

耳鼻喉科耳鼻喉科耳鼻喉科
传染性疾病传染性疾病
药理学药理学是指药理学的学科.

背景情况:

前鼻往往需要前鼻包装 (ANP) 进行静血.
预防性抗生素是某些程序的标准,但在ANP后免疫抑制患者中存在争议.
这项研究调查了这一特定患者群体的感染和不良药物反应率.

研究的目的:

评估在接受ANP的免疫抑制患者中预防性抗生素的疗效和安全性.
为了比较抗生素和非抗生素组之间的临床重要感染 (CSI) 和药物不良反应 (ADR) 的比率.
为了告知临床实践关于在这个脆弱人群中使用抗生素.

主要方法:

利用了TrinetX全球研究网络数据库 (多达1.3亿名患者).
包括ANP和免疫抑制状态的成年患者,比较访问后一天内服用抗生素的情况.
进行了倾向性得分匹配,随后对CSI和ADR率进行了分析.

主要成果:

分析了2236名倾向匹配患者 (每组1118人);平均年龄69岁,女性41-42%.
观察到临床重要感染 (CSI) 的比例相似:对照组6.4%,抗生素组7.4% (P=0.25).
药物不良反应 (ADR) 的发生率也相似 (19.7%与22.1%,P=0.10),但ADR比CSI更频繁.

结论:

预防性抗生素并没有降低ANP后免疫抑制患者的临床显著感染率.
药物不良反应的发生率在各组之间相似,但高于感染率.
临床医生在为这些患者选择预防性抗生素时,应考虑抗生素管理和不良反应.

关键词:

在前方的包装.这种表现的表现是Epistaxis.免疫系统受抑制的人.预防性抗生素预防性抗生素

更多相关视频

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

Published on: January 2, 2017

Characterization of Inflammatory Responses During Intranasal Colonization with Streptococcus pneumoniae

Characterization of Inflammatory Responses During Intranasal Colonization with Streptococcus pneumoniae

Published on: January 17, 2014

相关概念视频

Epistaxis

Epistaxis

Epistaxis, or nosebleeds, occurs when small, swollen blood vessels in the nasal mucous membrane rupture. Typically, the anterior septum is the primary site of occurrence.
Etiology
Possible causes of this condition include high blood pressure, trauma, low humidity, upper respiratory tract infections, allergies, foreign bodies, nasal inhalation of corticosteroids or illicit drugs, excessive use of decongestant nasal sprays, facial or nasal surgery, anatomic malformation, tumors, or systemic...

Transmission-based Precautions II: Airborne and Protective Environment

Transmission-based Precautions II: Airborne and Protective Environment

Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...

Pneumonia IV: Management

Pneumonia IV: Management

The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include: