在连续的冷热刺激下,对具有温度依赖性质的皮肤组织的热力学相互作用进行数值研究
Yingze Wang1, Zhaowei He1, Sheng Zhang1
1School of Energy and Power Engineering, Jiangsu University, Zhenjiang, 212013, PR China.
Journal of thermal biology
|November 13, 2025
概括
低温喷雾冷却与脉冲激光照射相结合,可以治疗深层皮肤病变. 这项研究模拟了热力学反应,发现冷喷雾冷却减少了表皮损伤,但增加了压力应激,需要均衡的治疗方案.
科学领域:
- 生物医学工程 生物医学工程
- 计算生物学 计算生物学
- 皮肤病学 皮肤病学
背景情况:
- 脉冲激光照射和冷喷雾冷却 (CSC) 显示出治疗诸如港口葡萄酒污点 (PWS) 等深层皮肤病变的前景.
- 优化这种联合疗法需要了解皮肤在连续热应力下复杂的热力学行为.
- 现有的模型可能无法完全捕捉由温度依赖性质和先进的传热机制影响的动态反应.
研究的目的:
- 为皮肤组织开发和验证一个全面的生物热力机械合模型.
- 研究脉冲激光和CSC治疗下多层皮肤的动态热力学反应和热损伤.
- 分析温度依赖性质和激光参数对治疗结果的影响.
主要方法:
- 开发一种结合的生物热力学模型,其中包含了取决于温度的材料特性.
- 实施双相滞后 (DPL) 生物热传递模型以模拟热传输.
- 使用有限差异方法预测温度,位移,应力和热损伤分布的数值解决方案.
- 在不同的条件和参数下对模拟结果进行比较分析.
主要成果:
- 该模型准确地预测了分层皮肤中的温度,位移,热应力和损伤分布.
- 温度依赖性质和激光参数显著影响热力学反应.
- 低温喷雾冷却 (CSC) 有效地减轻了表皮热损伤.
- CSC的应用会在皮肤组织中引发显著的压力应激.
结论:
- 开发的模型为联合激光和CSC治疗的生物热力学效应提供了关键的见解.
- 低温喷雾冷却提供了对表皮损伤的保护作用,但引入了机械应力.
- 均衡的临床方案对于优化疗效和尽量减少治疗深层皮肤病变的不良影响至关重要.
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