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Updated: Jan 11, 2026

Author Spotlight: Reprogramming Cancer Cells to iPSCs to Study Disease Progression and Treatment Targets
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在胰腺腺癌中通过抑制BRD4进行瘤性线粒体的重编程,导致被编程的细胞死亡

Chun Cai1, Michael W Spinrad2, Lauren C Gattie2

  • 1Department of Surgery, The University of Tennessee Health Science Center, Memphis, Tennessee; Center for Cancer Research, The University of Tennessee Health Science Center, Memphis, Tennessee.

The Journal of pharmacology and experimental therapeutics
|November 13, 2025
PubMed
概括

博莫代因和外部域 (BET) 抑制剂在胰腺管道腺癌 (PDA) 模型中激活了线粒细胞衰和铁. 这种新的治疗策略针对线粒体功能障碍,控制瘤和增强化学敏感性.

关键词:
和地外域域名癌症治疗方法 癌症治疗方法线粒体应激压力是什么线粒细胞衰变 (mitophagy) 是一种神经衰变的过程.胰腺管道腺癌瘤

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