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血管生成的双面:机制和治疗应用

Reza Izadpanah¹, Amin Izadpanah², Eckhard U Alt²

¹Applied Stem Cell Laboratory, Department of Medicine/Heart and Vascular Institute, Tulane University School of Medicine, New Orleans, LA, USA; Department of Surgery, Tulane University School of Medicine, New Orleans, LA, USA.

Biochimica et biophysica acta. Reviews on cancer

|November 13, 2025

概括

了解血管新生是治疗疾病的关键. 这篇评论对癌症进行了对比.

科学领域:

*分子生物学和细胞信号通路控制血管生成.
* 翻译医学将基础科学与临床应用联系起来.
* 瘤学和再生医学专注于血管调节.

背景情况:

*血管新生,新血管的形成,对于发育和修复至关重要.
*生理血管新生受到VEGF和FGF等生长因子的严格调节.
* 病态血管生成发生在癌症 (促进瘤生长) 和缺血性疾病 (阻碍修复) 中.

研究的目的:

* 为了比较和对比恶性和非恶性血管生成的分子和临床方面.
* 批判性地评估针对血管生成的当前和新兴治疗策略.
*为根据疾病背景量身定制血管生成向干预措施提供路线图.

主要方法:

*在不同血管源背景下对分子通路 (例如,MAPK,PI3K-AKT,VEGFR2信号传递) 的比较分析.
*对治疗方法的审查,包括VEGF抑制剂,TKI,亲血管性因素和药物输送系统.
*评估生物标志物,如Ang-2,可溶性VEGFR2和VEGF异型比率,以指导治疗.

主要成果:

*恶性血管新生劫持核心通路,导致不受控制的内皮增殖和漏血血管.
* 瘤血管新生通过适应性路径上调来发展对VEGF阻断等疗法的耐药性.
*非恶性血管新生需要亲血管新生策略来恢复输液并促进修复.

结论:

* 区分癌症和非癌症血管生成对于治疗成功至关重要.
* 定制干预措施,抑制癌症,增强缺血性疾病,在临床上是决定性的.
*以生物标志物为指导的选择和组合方案对于有效的血管新生向疗法至关重要.

关键词:

血管新生的产生.以生物标志物为指导的治疗方法亲和抗血管性疗法和抗血管性疗法治疗耐药性是一种治疗性耐药性.在VEGF/VEGFR的信号中.

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