代谢功能障碍相关的脂肪肝与动脉样硬化,炎症和饮食习惯之间的性别特异关联
Gaston A Rodriguez-Granillo1, Rosana Poggio2, Alejandra B Rubilar3
1Department of Cardiovascular Imaging, Instituto Medico ENERI, Clinica La Sagrada Familia, Buenos Aires, Argentina.
Clinical nutrition ESPEN
|November 13, 2025
概括
与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 显示出与女性不良心脏代谢健康的更强的联系. 这项研究强调了MAFLD的性别特异性差异.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 代谢健康 代谢健康
背景情况:
- 与代谢功能障碍相关的脂肪肝疾病 (MAFLD) 有复杂的原因,与饮食有关.
- 需要对拉丁美洲的MAFLD及其性别特异性影响提供更好的数据.
- 这项研究调查了MAFLD与饮食,炎症和心脏病的联系.
研究的目的:
- 探索MAFLD,饮食习惯,全身炎症和冠状动脉样硬化之间的关系.
- 在拉丁美洲群体中检查这些关联的性别特异性.
主要方法:
- 包括799名30至75岁无症状的成年人接受心脏CT.
- 由肝硬化症加上代谢风险因素 (肥胖,糖尿病等) 定义的MAFLD. ) 的情况.
- 评估冠状动脉化 (CAC),实验室,心电图和心脏维度.
主要成果:
- MAFLD患者的HbA1C,甘油三和HDL-C都较高,心脏腔更大.
- 患有MAFLD的妇女与炎症 (hs-CRP),CAC和特定的饮食习惯 (加工肉类,含糖饮料) 有关.
- 患有MAFLD的男性的乳制品摄入量较低;多变量分析显示,男性和女性的MAFLD存在明显的独立风险因素.
结论:
- 在两性中,MAFLD与更糟糕的心脏代谢特征有关.
- 在女性中,在MAFLD和不良心脏代谢结果之间观察到更一致的关系.
- 调查结果强调了在MAFLD研究和管理中性别考虑的重要性.
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