亚裔美国儿童中食物蛋白诱导肠球炎综合征的特征
Charles Feng1, Priscilla Wong2, Satish Mudiganti3
1Division of Allergy/Immunology, Palo Alto Medical Foundation, Mountain View, California.
概括
这项研究突出了亚裔美国儿童食物蛋白诱导肠球炎综合征 (FPIES) 的独特特征,指出蛋是常见的触发因素,并较少的共同关联. 了解这些差异有助于在这个多样化的人口中诊断和管理FPIES.
科学领域:
- 儿科过敏和免疫学
- 胃肠病学 胃肠病学
- 临床营养学 临床营养学
背景情况:
- 关于亚裔美国儿童中食物蛋白诱导肠球炎综合征 (FPIES) 临床特征的数据有限.
- FPIES是一种影响胃肠道的非IgE介导过敏反应.
研究的目的:
- 在北加利福尼亚州的医疗保健系统中评估一组被诊断患有FPIES的ASA儿童.
- 为了确定这一群体中特定的临床特征和常见的触发性食物.
主要方法:
- 对2015年至2022年期间被诊断患有FPIES的18岁以下儿童的回顾性分析.
- 利用了患者/家长自我报告的种族/种族以及经过董事会认证的过敏学家的图表审查.
- 进行了市场篮子分析,以确定FPIES食品类别之间的相关性.
主要成果:
- 在129,989名ASA儿童 (0.11%) 中发现了146例急性FPIES病例.
- 受影响最多的是男性 (52%) 患有亚托皮炎 (55.5%);诊断时的中位数年龄为7个月.
- 常见的罪祸首的食物包括蛋 (36.3%),麦 (24%) 和牛奶 (16.4%);蛋触发与缺乏梨触发有关 (88%的信心).
结论:
- 这种大型儿科ASA FPIES队列表现出明显的特征,包括高患卵引起的FPIES.
- 观察到缺乏常见的食物协会,与其他种群不同.
- 认识到这些临床差异可以改善FPIES诊断和管理在不断增长的ASA人口.
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