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一种以过程为导向的方法,用于制造个性化的阴道内环,使用滴滴沉积建模

Nobel O Sierra-Vega¹, Manjusha Annaji¹, Muhammad Ashraf¹

¹Office of Pharmaceutical Quality Research, CDER, U.S. FDA, USA.

International journal of pharmaceutics

|November 13, 2025

概括

滴滴沉积建模 (DDM) 通过启用定制药物递送设备来推进个性化医疗. 优化打印参数,如灌注密度是定制的阴道内环 (IVRs) 控制药物释放的关键.

科学领域:

制药技术制药技术制药技术
添加剂制造添加剂制造添加剂制造
材料科学材料科学材料科学

背景情况:

个性化药物输送系统需要先进的制造技术.
阴道内环 (IVR) 是有效的局部药物输送.
滴滴沉积建模 (DDM) 提供了定制制制药生产的潜力.

研究的目的:

研究DDM打印参数对3D打印β- Estradiol IVRs特征的影响.
了解灌装密度 (ID),滴水面比 (DAR) 和放电率 (DR) 如何影响IVR性能.
为个性化药物递送应用程序优化DDM.

主要方法:

使用DDM3D打印充满β-雌激醇的IVR.
印刷参数的系统变化:ID,DAR和DR.
IVRs的特征包括形态,多孔性,重量,机械性质和体外药物释放.

主要成果:

DDM生产了具有高维度准确性和批量统一性的IVR.
增加的ID和DR增强了IVR的重量,硬度,机械强度和粘性弹性,同时减少了多孔性.
DAR变化显示出相反的效果. 较高的ID与缓慢的药物释放相关.

结论:

打印参数显著影响DDM制造的IVR特性和药物释放概况.
DDM是一种可行的技术,用于生产可调节药物释放的个性化IVR.
这项研究支持针对个性化药物的增材制造和分布式药物制造.

关键词:

通过3D打印打印3D打印.放电率放电率放电率放电率滴滴的视角比率是指滴滴的比例.滴滴沉积的建模.药物产品个性化是药物产品的个性化.填充密度是指填充的密度.阴道内环阴道内环

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