免疫疗法和向治疗在头部和部瘤学方面的考虑
Richard Dagher1, Alexander Khalaf1, Renata Ferrarotto2
1Department of Neuroradiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, Houston, TX 77030, USA.
Radiologic clinics of North America
|November 13, 2025
概括
针对头癌的免疫治疗提出了独特的成像挑战. 了解新的反应模式和与免疫相关的毒性对于准确的评估和有效的患者管理至关重要.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 免疫学 免疫学 免疫学
背景情况:
- 免疫疗法为头癌提供了新的治疗途径.
- 新型治疗方式,如免疫检查点抑制剂,CAR-T细胞疗法和瘤病毒,诱导独特的反应模式.
- 这些反应,以及与免疫相关的毒性,可以使传统的成像评估复杂化,并模仿疾病的进展.
研究的目的:
- 为了突出解释脑癌患者接受免疫治疗的成像的复杂性.
- 强调需要了解非典型的治疗反应和与免疫相关的不良事件.
- 强调放射科医生在准确评估和管理中的作用.
主要方法:
- 关于头癌免疫治疗的当前文献的综述.
- 讨论新的反应模式,包括伪进展,超进展,分离反应和持久反应.
- 修改成像标准的评估,例如iRECIST和imPERCIST.
主要成果:
- 免疫疗法引起了不同的瘤反应模式,与传统治疗不同.
- 免疫相关的毒性可以在放射学上呈现,模仿疾病的进展或复发.
- 修改成像标准 (iRECIST,imPERCIST) 可以提高反应评估的准确性.
结论:
- 在头癌免疫疗法中对成像的准确解释需要对治疗机制和非典型反应的专业知识.
- 放射科医生对于区分治疗效应与疾病进展以及识别与免疫相关的不良事件至关重要.
- 采用最新的成像标准和了解免疫相关现象对于最佳的患者管理和治疗延续至关重要.
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