Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance01:25

Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance

173
In healthy individuals, serum creatinine levels remain stable due to a balance between its constant production—primarily from muscle metabolism—and renal excretion. Creatinine is freely filtered by the glomeruli, making it a valuable marker for estimating renal function. When the glomerular filtration rate (GFR) decreases, the kidneys can only eliminate less creatinine, causing serum levels to rise.Serum creatinine concentration is widely used to estimate creatinine clearance...
173
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

178
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
178
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

197
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
197
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

354
Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
354
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

182
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
182
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

237
Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
237

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

[Comparison of the efficacy and safety of venetoclax plus azacitidine versus D-CAG regimen in the treatment of elderly patients with relapsed or refractory acute myeloid leukemia].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi·2026
Same author

[Clinical classification of pediatric non-alcoholic fatty liver disease based on pancreatic islet function].

Zhonghua er ke za zhi = Chinese journal of pediatrics·2026
Same author

Anomalous random neural network's guide to Hopfield neural networks.

Chaos (Woodbury, N.Y.)·2026
Same author

[Advances in the epigenetic mechanisms of maternal obesity on offspring metabolic health].

Zhonghua er ke za zhi = Chinese journal of pediatrics·2025
Same author

[A meta-analysis of efficacy and safety of anti-obesity medications in the treatment of childhood obesity].

Zhonghua yi xue za zhi·2025
Same author

[The application of robot-assisted laparoscopic resection of primary retroperitoneal tumors via the abdominal approach].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2025

相关实验视频

Updated: Jan 11, 2026

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

18.1K

[确定正常体重儿童尿酸的参考间隔]

G H Li1, Y Y Meng1, Y X Li1

  • 1Department of Endocrinology, the Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China.

Zhonghua er ke za zhi = Chinese journal of pediatrics
|November 13, 2025
PubMed
概括

儿童血清尿酸参考间隔因年龄和性别而异. 男孩通常有更高的水平,这也与年龄和青春期发育相关,影响儿科健康评估.

更多相关视频

Biochemical Measurement of Neonatal Hypoxia
13:13

Biochemical Measurement of Neonatal Hypoxia

Published on: August 24, 2011

14.4K
Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis
07:45

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis

Published on: February 9, 2021

4.0K

相关实验视频

Last Updated: Jan 11, 2026

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
07:56

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

Published on: January 29, 2018

18.1K
Biochemical Measurement of Neonatal Hypoxia
13:13

Biochemical Measurement of Neonatal Hypoxia

Published on: August 24, 2011

14.4K
Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis
07:45

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis

Published on: February 9, 2021

4.0K

科学领域:

  • 儿科内分泌学 儿科内分泌学
  • 临床化学 临床化学
  • 生物统计学 生物统计学

背景情况:

  • 血清尿酸是一种代谢副产品,对儿科健康有影响.
  • 确定准确的参考间隔对于诊断儿童的代谢和脏疾病至关重要.
  • 已知年龄,性别和青春期状态等因素会影响尿酸水平.

研究的目的:

  • 确定1个月至15岁正常体重儿童血清尿酸的参考间隔.
  • 分析性别,年龄和青春期发育对该儿科队列血清尿酸水平的影响.

主要方法:

  • 一项涉及7910名正常体重儿童的横截面研究.
  • 收集的数据包括性别,年龄,青春期症状 (坦纳阶段) 和血清尿酸水平.
  • 统计分析包括相关性,部分相关性和多变量线性回归,以确定影响因素并建立参考间隔 (P5-P95).

主要成果:

  • 在大多数年龄组中,男孩的血清尿酸水平明显高于女孩 (P<0.05).
  • 尿酸水平与年龄 (r=0.47,P<0.001) 和BMI Z-score (r=0.11,P<0.001) 有正相关性.
  • 在年龄较大的儿童 (6-16岁) 中,男孩的尿酸水平与坦纳阶段 (r=0.10-0.27,P<0.05) 呈正相关性,与女孩不同.

结论:

  • 儿童血清尿酸参考间隔在不同年龄组和性别之间存在显著差异.
  • 性别和青春期状态是儿童血清尿酸水平的关键决定因素.
  • 这些发现需要特定于年龄和性别的参考范围来准确的临床解释.