基于穿戴式传感器的步态测量可以准确地反映帕金森病的严重程度吗? 一个系统的审查和元分析
Hussein Youssef1, Mert Sabıroğlu2, Sama Mahmoud Abdel-Rahman2
1University of Minnesota, Department of Neurology, Movement Disorders Laboratory, Minneapolis, MN, USA; Koç University, Research Center for Translational Medicine (KUTTAM), İstanbul, Türkiye; Koç University Graduate School of Health Sciences, İstanbul, Türkiye; Street Doctor, Alexandria, Egypt.
Parkinsonism & related disorders
|November 13, 2025
概括
惯性测量单位 (IMU) 可以通过分析步态来客观评估帕金森病 (PD) 的严重程度. 来自IMU的步态参数与临床尺度相关,为传统的PD评估提供了定量补充.
科学领域:
- 生物医学工程 生物医学工程
- 神经学 神经学
- 数字健康数字健康
背景情况:
- 经典帕金森病 (PD) 的评估是主观和可变的.
- 可穿戴惯性测量单元 (IMU) 为PD提供了定量步态分析.
- 步行异常是PD进展的关键指标.
研究的目的:
- 评估IMU用于检测PD运动症状严重程度.
- 检查IMU步行参数和PD尺度 (MDS-UPDRS III,H&Y,PIGD) 之间的关系.
主要方法:
- 系统的文献搜索 (PubMed,科学网,科克兰).
- 包括的研究评估了IMU的步态,并与PD尺度相关联.
- 提取了关于研究特征,参与者,传感器和协议的数据.
主要成果:
- 包括93项研究;21项在元分析中.
- 较慢的步行速度与较高的MDS-UPDRS III和H&Y分数相关.
- 严重的PD显示更短的步长,更长的立场时间,更慢的转速 (MDS-UPDRS III);减少的步长,脚,冲击角度 (H&Y).
- 大多数IMU专注于下肢动力学 (脚,腰).
结论:
- 步行速度,姿势时间和冲击角度是PD严重程度的有希望的客观数字生物标志物.
- IMU可以补充传统的临床PD评估.
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