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增加感知可靠性降低了皮层神经元中的膜潜力变化

Ben von Hünerbein¹, Jakob Jordan^2,3, Matthijs Oude Lohuis^4,5

¹Department of Physiology, University of Bern, Bern 3012, Switzerland ben.vonhuenerbein@unibe.ch.

The Journal of neuroscience : the official journal of the Society for Neuroscience

|November 13, 2025

概括

皮层神经元在处理可靠的感官信息时会减少它们的内部电变性,这反映了大脑在决策过程中如何跟踪不确定性.

科学领域:

神经科学是一个神经科学.
计算神经科学是一种神经科学.
决策决策决策决策

背景情况:

不确定性是跨物种决策的关键因素.
在大脑皮层中,对不确定性的神经表现还不太清楚.
理论模型预测了通过刺激触发的不确定性计算来减少神经元膜潜力的变化.

研究的目的:

调查皮层神经元如何表示和响应刺激的可靠性和不确定性.
在体内测试减少膜电位变量的理论预测.
探索后壁皮层神经元在多感官决策中的作用.

主要方法:

利用基于模拟的推断来分析单元记录中的膜电位统计数据.
从雄性小鼠的后壁皮层神经元中记录,这些神经元执行多感官变化检测任务.
检查了刺激可靠性和神经元膜潜能变异性之间的关系.

主要成果:

推断膜电位统计显示,响应任务相关刺激的可变性下降.
与不太可靠的刺激相比,更可靠的刺激诱导了膜潜力变化率的更大降低.
这些发现与皮层神经元中不确定性跟踪的理论预测一致.

结论:

皮层神经元动态调整它们的膜电位变化以追踪不确定性.
这种机制为下游神经计算提供了贝叶斯的好处.
这项研究提供了对不确定性下决策的神经基础的见解.

关键词:

贝叶斯计算是贝叶斯的计算.膜潜力膜潜力膜潜力后面的顶层皮层皮层.基于模拟的推理主题/话题不确定性表示不确定性表示.不同性的火灭.

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