人类肠道真菌Clavispora lusitaniae通过Pyruvate脱碳酶衍生的Indole-3-乙醇减轻大肠炎
Fan Wu1,2, Yan Wang2, Zhenpeng Mai1
1Pharmaceutical Research Center, Second Affiliated Hospital, Dalian Medical University, Dalian, China.
Nature communications
|November 13, 2025
概括
Clavispora lusitaniae P4013B 是一种在炎症性肠病 (IBD) 中枯竭的肠道真菌,可以缓解小鼠的结肠炎. 它的代谢物, indole-3-乙醇,激活烯碳化合物受体 (AHR),提供作为IBD益生菌的潜力.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 肠道真菌生物组失调与炎症性肠病 (IBD) 病原发生有关.
- 菌物种在IBD发展中的特殊作用需要进一步研究.
研究的目的:
- 确定可能影响IBD的特定肠道真菌.
- 在结肠炎模型中研究Clavispora lusitaniae P4013B的治疗潜力.
主要方法:
- 来自IBD队列的便元基因组数据集的分析.
- 评估C. lusitaniae P4013B对小鼠DSS诱导的大肠炎的影响.
- 使用活动导向隔离方法识别活性代谢物.
- 工程微生物菌株用于增强代谢物生产.
主要成果:
- 鉴定出C. lusitaniae P4013B是一种IBD枯竭的真菌.
- P4013B通过激活基碳化合物受体 (AHR) 来减轻DSS诱导的大肠炎.
- 印度醇-3-乙醇 (IEt) 被确定为负责抗结肠炎活性的AHR激动剂.
- 茶叶多糖增强了P4013B的有效性,通过促进其肠道殖民.
结论:
- C. lusitaniae P4013B表现出通过IEt和AHR激活调解的抗结肠炎特性.
- 产生IET的工程菌株显示出治疗潜力.
- C. lusitaniae P4013B值得进一步探索作为IBD预防和治疗的益生菌.
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