固体瘤中的多细胞免疫生态型预测了免疫检查点抑制剂的实际治疗效益
Xuefeng Wang1, Tingyi Li2, Islam Eljilany3
1Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA. Xuefeng.Wang@moffitt.org.
Nature communications
|November 13, 2025
概括
癌瘤生态型反映了癌症与免疫相互作用,可以预测患者对免疫检查点抑制剂 (ICI) 的反应. 这项研究验证了生态型作为癌症,特别是黑色素瘤的预后生物标志物,为指导ICI治疗提供了现实世界的证据.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 计算生物学 计算生物学
背景情况:
- 免疫检查点抑制剂 (ICI) 已经彻底改变了癌症治疗.
- 预测患者对ICI的反应仍然是一个重大的临床挑战.
- 癌瘤生态型,代表癌症-免疫相互作用,显示作为生物标志物的潜力,但需要现实世界的验证.
研究的目的:
- 定义和评估ICI治疗的癌症患者中癌症生态型的预后和预测价值.
- 开发和验证一种针对黑色素瘤的ICI预测模型.
- 在ICI治疗中建立基于生态型的临床决策框架.
主要方法:
- 对ORIEN Avatar ICI队列 (1610名患者) 和更广泛的数据集 (14,997个人) 分析,其中包括基因表达数据.
- 基于EcoTyper的免疫类型定型,以定义生态型并评估它们与生存结果的关联.
- 使用临床试验和外部数据集开发和验证一种针对黑色素瘤的ICI预测模型.
主要成果:
- 不同的细胞状态和生态型始终与各种癌症类型的生存结果有关.
- 开发的黑色素瘤特异性ICI预测模型显示了显著的验证.
- 现实世界的证据支持生态型作为预后和预测生物标志物的翻译效用.
结论:
- 癌瘤生态型为了解癌症与免疫相互作用提供了一个强大的框架.
- 基于生态型的免疫类型为指导ICI治疗提供了临床可行的见解.
- 这项研究确定了生态型在瘤学中的现实世界预后和预测价值.
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