缺少TEX51的精子表现出低生育性和形态学上的缺陷
Sophie Dupuis1, Morgane Le Beulze1, Tyler D R Vance2
1Institut Cochin, CNRS, INSERM, Université Paris Cité, Paris, France.
Communications biology
|November 13, 2025
概括
研究人员确定TEX51是IST超级家族的新成员,对受精至关重要. 德克斯51的淘汰赛小鼠表现出不孕症和精子缺陷,揭示了它在精子形成中的作用.
科学领域:
- 生殖生物学 生殖生物学
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 受精对于繁殖至关重要,但其分子机制尚未完全理解.
- IST (不孕不育和精子生成目标) 超级家族蛋白质是受精的关键参与者.
- 之前的研究已经确定了这个家族中的IZUMO1,SPACA6和TMEM95.
研究的目的:
- 通过基于结构的蛋白质组搜索来识别IST超级家族的新成员.
- 为了研究新发现的蛋白质TEX51在哺乳动物受精中的功能.
- 阐明TEX51在精子发育和男性生育能力中的作用.
主要方法:
- 基于结构的AlphaFold人类蛋白质组的搜索,以确定潜在的IST超级家族成员.
- 对TEX51结构,表达和保存的生物信息分析.
- 生成和分析一个Tex51-Knockout (KO) 鼠标模型.
- 在体内和体外生育能力评估,精子运动性分析和电子显微镜.
主要成果:
- TEX51被确定为一种新的IST超级家族蛋白质,其结构与已知的成员相似.
- 在Tex51-KO雄性小鼠中,尽管精子运动正常,但表现出低生育性.
- KO精子表现出形态异常,包括鞭毛断层,细胞质残留物和体核 anchoring缺陷.
结论:
- 在哺乳动物的男性生育能力中,TEX51起着至关重要的作用.
- IST超级家族的功能超出了伴生体相互作用的范围,在精子发生过程中形成精子.
- TEX51对于适当的精子形态和发育至关重要,影响生殖成功.
相关概念视频
Spermatogenesis
121.5K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
121.5K
Spermatogenesis
8.8K
Spermatogenesis is a complex process that involves the development of sperm cells from undifferentiated stem cells in the seminiferous tubules of the testes. The process is essential for the production of mature and functional sperm cells that are capable of fertilizing an egg.
The process of spermatogenesis can be divided into mitosis, meiosis, and spermiogenesis. During mitosis, the spermatogonia or stem cells divide to produce two identical daughter cells, type A and B spermatogonia. Type-A...
The process of spermatogenesis can be divided into mitosis, meiosis, and spermiogenesis. During mitosis, the spermatogonia or stem cells divide to produce two identical daughter cells, type A and B spermatogonia. Type-A...
8.8K
Infertility in Males
519
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
519
Fertilization
89.4K
During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...
89.4K
Sperm Transport
3.1K
The journey of sperm from its origin to the point of ejaculation begins within the seminiferous tubules of the testis. Here, Sertoli cells produce fluid that propels non-motile sperm through a series of conduits, starting with the straight tubules leading to the rete testis. This interconnected network of tubules acts as the initial pathway for sperm, guiding them into the efferent ductules and then into the epididymis for maturation.
The maturation phase occurs in the epididymis, where sperm...
The maturation phase occurs in the epididymis, where sperm...
3.1K
Sperm Structure and Semen Composition
10.1K
During ejaculation, males release around 2-5 milliliters of semen, which is a complex mixture of mature sperm and various fluids produced by accessory glands. The mature sperm cells measure approximately 60 micrometers in length and consist of a head, neck, midpiece, and tail. The head is flattened and tapered, measuring about 4 to 5 micrometers in length. It contains a nucleus with condensed chromosomes and an acrosome, a cap-like structure filled with enzymes essential for penetrating the...
10.1K


