护卫细胞RNA结合蛋白SAIR1的病原体诱导的凝结为免疫的微调翻译
Qiangsheng Yu1, Jie Wu2, Yunfan Jin2
1State Key Laboratory of Green Biomanufacturing, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China.
Nature plants
|November 13, 2025
概括
植物保护细胞使用STOMATAL IMMUNE RNA-BINDING PROTEIN 1 (SAIR1) 凝聚剂来增强防御mRNA的翻译和关闭胃. 这个过程是由病原体感知和激酶信号触发的,这对植物免疫至关重要.
科学领域:
- 植物生物学 植物生物学
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 植物中的守护细胞对于防御至关重要,控制口腔关闭以防止病原体进入.
- 生物分子凝聚物对于细胞过程至关重要,但它们在守护细胞免疫力中的作用是未知的.
- 了解这些机制是提高植物防御策略的关键.
研究的目的:
- 为了识别参与护卫细胞介导的口腔免疫的新生物分子凝聚物.
- 阐明这些凝结物调节植物防御反应的分子机制.
- 研究RNA结合蛋白在植物免疫信号传递中的作用.
主要方法:
- 在护卫细胞中识别和表征胃免疫RNA结合蛋白1 (SAIR1).
- 调查SAIR1在相位分离和凝结物形成中的作用.
- 分析SAIR1凝聚物对与防御相关的mRNA翻译和口腔关闭的影响.
主要成果:
- 一种RNA结合蛋白SAIR1通过相分离在护卫细胞中形成病原体反应凝聚物.
- MPK3和MPK6激酶酸化SAIR1,在flg22感知时触发凝结物形成.
- SAIR1凝聚隔离防御mRNA并增强它们的翻译,促进口腔关闭和免疫力.
结论:
- 酸化调节的SAIR1凝聚物作为守护细胞中的关键信号枢纽.
- 这些凝结物将病原体感知 (flg22-MPK3/6) 与口腔免疫联系起来.
- 这项研究揭示了在转录后水平调节植物防御的新机制.
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