腹部脂肪组织细分对基于放射学的预后评估的影响,使用克罗恩病中CT肠道学
Feini Zhou1, Jiwei You1,2, Yifan Guo1
1Department of Radiology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), 54 Youdian Road, Hangzhou, Zhejiang, 310006, China.
BMC medical imaging
|November 13, 2025
概括
在克罗恩氏病 (CD) 患者的内脏脂肪组织 (VAT) 的整个腹部细分产生了预测疾病进展的最佳放射学模型. 这种细分策略对于准确的结果预测至关重要.
科学领域:
- 放射学 放射学是一门学科.
- 医疗成像医学成像
- 在瘤学瘤学.
背景情况:
- 克罗恩氏病 (CD) 管理需要准确预测疾病进展.
- 对CT肠道成像 (CTE) 的放射学分析显示,对预测CD结果有希望.
- 腹部脂肪组织细分策略可能会影响放射学模型的性能.
研究的目的:
- 评估不同腹部脂肪组织细分方法对放射学模型的影响,以预测CD患者的3年疾病进展.
- 为了比较基于全腹部,单片和脊椎水平脂肪组织细分的放射学模型的预后性能.
主要方法:
- 追溯双中心研究,包括接受基线CTE的CD患者.
- 用三种策略对内脏脂肪组织 (VAT) 和皮下脂肪组织 (SAT) 进行细分:全腹部 (T-VAT/SAT),单片受影响的部分 (LL-VAT/SAT) 和单片脊椎水平 (V-VAT/SAT).
- 放射性特征提取,选择 (LASSO),后勤回归建模,并构建一个联合的临床-放射性模型. 由ROC,AUPRC和DCA评估的性能.
主要成果:
- 整个腹部增值税 (T-VAT) 模型在外部测试中表现优异,AUC为0.877和AUPRC为0.657.
- 结合了临床特征和T-VAT的组合模型实现了最高的AUPRC (0.666) 和可比的AUC (0.873).
- 决策曲线分析证实了组合模型比单独的T-VAT和临床模型具有更高的临床净效益.
结论:
- 使用全腹部增值税细分的放射学为预测CD进展提供了最佳的预后性能.
- 选择腹部脂肪组织细分策略对于开发可靠的放射学模型来预测CD的结果至关重要.
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