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脑小血管疾病得分与大脑低流相关,预测认知能力下降:一项纵向研究

Xiaoqian Zhang¹, Sirui Liu², Bo Hou¹

¹Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing, 100730, China.

BMC medical imaging

|November 13, 2025

概括

大脑小血管疾病 (CSVD) 的负担与大脑血流减少有关,并预测老年人的认知能力下降. 较高的CSVD分数表明未来认知障碍的风险增加.

科学领域:

神经学神经学
放射学放射学是一门学科.
老年学是一门学科.

背景情况:

大脑小血管疾病 (CSVD) 在老年人群中很常见.
研究CSVD负担和脑血流 (CBF) 之间的联系对于理解认知衰老至关重要.
识别用于预测认知衰退的成像标志物是老年医学研究的一个关键目标.

研究的目的:

评估认知完整的老年人中总CSVD负担得分和基线CBF之间的关联.
为了确定CSVD得分是否可以预测未来的认知障碍.
探索CSVD评分作为一种潜在的成像生物标志物,用于衰老中的认知健康.

主要方法:

509名认知正常的老年人接受了MRI,包括pCASL对CBF和T1加权扫描.
用5分尺度量化CSVD负担,评估白质过强度,缺口,周血管空间和微型血液.
纵向认知功能在平均7.6年内被评估;统计分析包括单变线性模型,逻辑回归和ROC曲线分析.

主要成果:

较高的CSVD得分与皮层区域显著减少的CBF相关 (P_adj<0.05).
具有较高CSVD分数的个体表现出对纵向认知衰退的敏感性增加 (OR 2.995,P=0.001).
该CSVD得分模型在预测认知障碍方面表现出高准确度 (AUC=0.808),截止点等级>2.

结论:

严重的CSVD,以较高的得分为标志,与皮质低 perfusion 相关,并预测纵向认知衰退.
CSVD评分是有效的成像标记,用于识别有认知障碍风险的个体.
CSVD评分提供了一个临床上可访问的工具,用于风险分层和个性化的健康监测老龄化人口.

关键词:

动脉旋转标签的标签大脑的血液流动.大脑小血管疾病大脑小血管疾病认知障碍认知障碍是一种认知障碍.纵向研究是一项纵向研究.

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