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溶性泌尿酸酶等离子体激活剂受体和外科手术期间的并发症:一个系统的审查
Ata B Gungor1,2, Prateek Pennathur3, Hamza S Guran3
1Department of Medicine, McMaster University, Hamilton, ON, Canada. ataboran0677@gmail.com.
BMC anesthesiology
|November 13, 2025
概括
可溶性尿素激酶类型等离子体激活受体 (suPAR) 显示出预测手术并发症的潜力,特别是急性损伤. 需要进一步的研究来证实其临床价值及其关联的程度.
科学领域:
- 手术风险分层的分层化
- 生物标志物发现发现
- 在外科手术期间的医学.
背景情况:
- 改进的风险分层工具对于手术患者至关重要.
- 可溶性尿基酶类型等离子体激活受体 (suPAR) 在预测术后并发症方面表现有前途.
研究的目的:
- 系统地审查外科手术和术后并发症的suPAR水平之间的关联.
主要方法:
- 在2024年10月之前对Embase和PubMed进行系统审查.
- 包括关于suPAR和手术后90天内外科并发症的研究.
- 使用QUIPS和GRADE评估的偏差风险和推断确定性.
主要成果:
- 18项研究 (6410名患者) 评估了suPAR和术后结果.
- 中等确定性 suPAR与急性损伤之间的关联.
- 对于与死亡率,复合结果,资源利用和感染的关联,确定性低至非常低.
结论:
- 在手术前测量的血清/血suPAR可能与术后并发症有关,特别是急性损伤.
- suPAR的规模和临床实用性需要在大型前性研究中与其他生物标志物进行验证.
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