酸对增长表现,肠道组织形态,抗氧化状态和盲体微生物群的作用 在被阿弗拉托克素B1挑战的 brojlers 中
Zhengfan Zhang1, Bingbing Ren1, Shuoshuo Lv1
1Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan 430023, China.
Journal of animal science
|November 14, 2025
概括
酸 (GA) 补充剂通过抵消阿弗拉托克辛B1 (AFB1) 作用,改善了 brojler 的健康. GA增强了抗氧化剂状态,肠道形态和有益的肠道细菌,同时减少了有害的细菌.
科学领域:
- 动物科学动物科学
- 毒理学 毒理学 毒理学
- 微生物学 微生物学
背景情况:
- 甲素B1 (AFB1) 对家禽健康构成重大威胁,影响其生长,器官功能和肠道微生物群.
- 氧化应激和肠道损伤是肉中AFB1暴露的关键后果.
- 酸 (GA) 是一种天然的化合物,具有抗氧化特性,可以减轻毒素引起的损伤.
研究的目的:
- 为了研究酸 (GA) 对牛肉的 aflatoxin B1 (AFB1) 毒性的保护作用.
- 评估GA对生长表现,肠道形态,抗氧化剂状况和膜微生物群组成的影响.
主要方法:
- 一个2x2完全随机的设计被用于480只肉,涉及AFB1挑战和GA补充.
- 肉被食含有250毫克/公斤GA和/或500微克/公斤AFB1.1的饮食.
- 评估的参数包括器官指数,血麦隆迪甲基,抗氧化酶活性,阴茎形态,基因表达 (CYP450,KLF) 和阴茎微生物群的多样性和组成.
主要成果:
- 在AFB1被挑战的 brojlers中,GA补充剂降低了肝脏和脏指数和血的malondialdehyde.
- GA增强了抗氧化酶活动,改善了骨结构,抵消了AFB1引起的损伤.
- GA调节了膜微生物群,增加了有益的细菌 (乳杆菌,链球菌,蓝菌) 和减少有害的细菌 (细菌菌,Escherichia-Shigella),同时恢复了α和β多样性.
结论:
- 用250mg/kgGA补充饮食有效地减轻了500μg/kgAFB1在 brojlers的负面影响.
- GA改善了肠道形态,增强了肝脏的抗氧化状态,并减少了氧化损伤和病理性器官增殖.
- GA积极调节了眼膜微生物群,减轻了AFB1对肠道微生物平衡的有害影响.
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