综合代谢流量平台用于分析,上下文化和定位 (IMPACT):弥合非定位和定位的流量分析
Collin Starke1, Janneke Hendriks2, Judith Wahrheit3
1Department of Bioinformatics and Biochemistry, Technische Universität Braunschweig, Niedersachsen, Braunschweig 38106, Germany.
Bioinformatics (Oxford, England)
|November 14, 2025
概括
综合代谢流动平台用于分析,上下文化和定位 (IMPACT) 通过准确计算质量同位素分布和上下文化未知的代谢物来帮助代谢学研究. 这个平台提高了精确地阐明代谢途径和网络.
科学领域:
- 代谢学 代谢学 代谢学
- 系统生物学 系统生物学
- 生物信息学是一种生物信息学.
背景情况:
- 代谢学研究在分析稳定同位素标记数据方面面临挑战.
- 准确计算质量同位素分布 (MID) 和代谢物注释对于途径阐明至关重要.
- 现有平台可能缺乏针对性和非针对性代谢学的全面整合.
研究的目的:
- 引入综合代谢流动平台用于分析,上下文化和定位 (IMPACT).
- 为先进的代谢学数据分析提供一个模块化平台,包括MID计算和代谢物上下文化.
- 促进新陈代谢数据与生物通路网络的整合.
主要方法:
- 影响集成了一个完整的LC-MS数据预处理管道:峰值选择,特征分组和峰值填充.
- 该平台包含了用于同位素检测和质量同位素分布 (MID) 计算的高级功能.
- 一个核心的上下文化算法注释未知的代谢物并将它们集成到生物通路网络中.
主要成果:
- 影响可以准确计算质量同位素分布 (MID).
- 该平台使用上下文化算法成功注释未知的代谢物.
- 代谢物数据有效地集成到生物通路网络中进行全面分析.
结论:
- 影响是一个全面的模块化平台,用于有针对性和非有针对性的代谢学.
- 该平台解决了代谢学研究的关键挑战,提高了精度和可靠性.
- 用户友好的在线访问和对各种文件格式的支持提高了研究人员的可访问性.
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