性别特定的进化程序塑造了家庭小鼠的重组率进化
Lydia K Wooldridge1, Micah Pietraho1, Peyton DiSiena1
1The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, United States.
Genetics
|November 14, 2025
概括
在室内小鼠 (Mus musculus) 中,雄性重组率显示出强烈的进化信号,与雄性不同,与雌性不同. 有证据表明,在M. m. musculus亚种系中,雄性重组的适应性增加.
科学领域:
- 进化生物学是进化的生物学.
- 遗传学 遗传学 是一个
- 进行比较的基因组学.
背景情况:
- 重组率在物种,种群和性别之间表现出显著的差异.
- 室内小鼠 (Mus musculus) 在重组率上表现出极大的差异,雄性比雌性更有差异.
- 性别限制的变异表明,在M. musculus中,男性和女性的重组率存在着不同的进化机制.
研究的目的:
- 为了正式评估不同的进化机制的假设,用于男性和女性的重组率在肌肉肌肉,使用一个家族遗传框架.
- 调查Mus物种和M. musculus亚种中性别特异性重组率的遗传分布和进化史.
主要方法:
- 从6000多个介质细胞中编制了大量的性别特定交叉率估计数据集.
- 包括来自31个基因多样化的同胞生育小鼠菌株的数据,分别来自5个Mus物种和4个M. musculus亚种.
- 结合了细胞遗传学估计与已公布的数据进行遗传学分析.
主要成果:
- 男性的重组率显示出强烈的家族遗传信号 (HP2 = 0.82),由Mus家族遗传学预测得很好.
- 女性的重组率表现出较弱的遗传学信号 (HP2 = 0.24).
- 与其他M. musculus亚种雄性相比,M. m. musculus雄性表现出明显的重组率增加,有适应性血统特异性进化的证据.
结论:
- 在室内小鼠中,重组率的进化是由不同的性别特异性的进化模式所支配的.
- 这些发现支持了男性和女性重组率存在单独进化途径的假设.
- 激励未来研究性别特异性选择性压力和影响重组的遗传架构.
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