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Updated: Jan 11, 2026

Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
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改变CH激活机制:对Rh催化非替代的功能化实验和计算研究

Christopher W Reid1, Chi Zhang2, Lauren E Baptiste1

  • 1Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, United States.

Organometallics
|November 14, 2025
PubMed
概括

本研究详细介绍了使用催化剂的替代的区域选择性乙烯化. 1,2-非替代相对1,3-非替代的反应速度要快得多,因为它具有固态可访问性.

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Unlike the easy catalytic hydrogenation of an alkene double bond, hydrogenation of a benzene double bond under similar reaction conditions does not take place easily. For example, in the reduction of stilbene, the benzene ring remains unaffected while the alkene bond gets reduced. Hydrogenation of an alkene double bond is exothermic and a favorable process. In contrast, to hydrogenate the first unsaturated bond of benzene, an energy input is needed; that is, the process is endothermic. This is...
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Simple aryl halides do not react with nucleophiles. However, nucleophilic aromatic substitutions can be forced under certain conditions, such as high temperatures or strong bases. The mechanism of substitution under such conditions involves the highly unstable and reactive benzyne intermediate. Benzyne contains equivalent carbon centers at both ends of the triple bond, each of which is equally susceptible to nucleophilic attack. This 50–50 distribution of products is...
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