在Mycobacterium Avium复杂肺部疾病中,时间转换到培养的临床影响
Nakwon Kwak1, Youngchan Cho1, Jiin Bae1
1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea.
Open forum infectious diseases
|November 14, 2025
概括
及时的培养转换对于治疗Mycobacterium avium复杂肺病 (MAC-PD) 是至关重要的. 患者在90天内没有实现培养转换,其微生物治疗机会较低,需要调整治疗策略.
科学领域:
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
- 微生物学 微生物学
背景情况:
- 在Mycobacterium avium复杂性肺病 (MAC-PD) 中评估治疗反应的最佳时间尚未确定.
- 本研究研究了培养转换时间和在MAC-PD患者中实现微生物治疗之间的联系.
研究的目的:
- 评估在MAC-PD患者的培养转换时间和微生物治疗之间的关联.
- 确定文化转换的关键时间点,从而预测治疗成功.
主要方法:
- 在首尔国立大学医院接受治疗的MAC-PD患者的回顾性研究 (2011年1月至2024年4月).
- 在12个月内实现培养转换的患者按转换时间 (0-30,31-60,61-90,91-180,181-360天) 分类.
- 多变量后勤回归分析了转换时间对微生物治疗的影响.
主要成果:
- 在440名患者中,294人 (66.8%) 实现了微生物治疗.
- 在91-180天 (aOR,0.45) 和181-360天 (aOR,0.29) 之间的培养转换与30天内转换相比,与更低的治愈几率有显著联系.
- 在31-60天或61-90天的转换时,没有观察到治愈率的显著差异.
结论:
- 不能在90天内实现培养转换与MAC-PD中微生物治愈的可能性显著降低有关.
- 这些发现强调了早期重新评估和对延迟培养转换的患者潜在的治疗修改的重要性.
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