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通过使用新型便携式质谱仪,快速量化和验证老鼠血液中埃托米达和德克斯梅托米丁度

Sicheng Liu^1,2, Xiaoxiao Li^1,2, Deying Gong²

¹Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.

Frontiers in veterinary science

|November 14, 2025

概括

一种新型的便携式质谱仪 (CELL) 能够快速,同时量化大鼠血中的埃托米达和德克斯梅托米丁. 这项技术支持精确的麻醉药物监测,并有可能用于护理点应用.

科学领域:

分析化学分析化学
药理学药理学是指药理学的学科.
临床麻醉临床麻醉

背景情况:

精确的麻醉剂量需要实时监测血液药物度.
目前用于快速定量药物的方法有限.
新型便携式质谱仪提供了一个潜在的解决方案.

研究的目的:

评估一个便携式质谱仪 (CELL) 用于快速量化老鼠血中埃托米达和德克斯梅托米丁的含量.
为了确定 50% 的有效剂量 (ED50) 的 etomidate 和 dexmedetomidine.
根据已建立的HPLC-MS方法验证CELL的性能.

主要方法:

使用上下方法来确定ED50值.
根据标准指南验证了CELL方法.
线性回归和类内相关系数 (ICC) 分析比较了CELL和HPLC-MS.

主要成果:

ED50值:埃托米达0.9毫克/千克,德克斯梅德托米丁21.1微克/千克.
对于这两种药物,CELL 显示出高线性和低量化极限 (LOQ).
在CELL和HPLC-MS之间观察到强烈的线性相关性 (ICC),表明了很好的协议.

结论:

细胞提供精确和快速的同时定量埃托米达和德克斯米德埃托米丁.
这个便携式系统支持临床麻醉实时药物监测.
在兽医和人类医学中,CELL显示出对临床监测 (POC) 的巨大潜力.

关键词:

在HPLC-MS中使用.德克斯梅德米丁 (Dexmedetomidine) 是一种制剂.乙基酸和乙基酸的关系质谱仪的质谱仪.快速分析快速分析鼠标鼠标鼠标鼠标鼠标

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