衰老和与任务相关的激活对脊髓传感器电路下降皮质调制的影响
Alejandro J Lopez1,2, Terrence J Glover3, Taylor M Leone2
1Neuroscience Graduate Program, Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA, the United States of America.
Aging brain
|November 14, 2025
概括
衰老显著改变脊柱反射调节,特别是在运动任务期间的老年人中. 这表明,随着年龄的增长,感觉运动整合发生了变化,影响了反射活动.
科学领域:
- 神经科学是一个神经科学.
- 人体生理学 人体生理学
- 衰老研究研究 衰老研究
背景情况:
- 下降的神经通路调节脊柱反射.
- 衰老会影响传感运动控制和神经处理.
- 脊柱反射调节随着年龄和任务要求而变化.
研究的目的:
- 为了研究与年龄相关的脊柱反射下降调节的差异.
- 检查任务条件 (休息,活跃,姿势) 如何影响年轻人和老年人的反射调节.
- 为了确定年龄和反射调节的大小之间的相关性.
主要方法:
- 采用双重的跨磁性刺激 (TMS) 和外周神经刺激 (PNS).
- 在不同的刺激间隔 (ISI) 和任务条件下测量霍夫曼 (H-) 反应.
- 在健康的年轻人 (YA) 和老年人 (OA) 之间比较反射调制.
主要成果:
- 与年轻人相比,老年人表现出明显不同的H-反射调节,在+40 ms ISI时,在积极坐着和静静的姿势中表现出明显不同的H-反射调节.
- 发现年龄和H-反射调节大小在+40 ms ISI之间存在显著的负相关性.
- 老年人表现出更大程度的H反射抑制.
结论:
- 老年人+40毫秒时与任务相关的脊柱反射调节发生变化 ISI表明与年龄相关的脊柱感觉运动整合的变化.
- 这些变化可能涉及下降路径,感官附带和脊柱电路内的复杂相互作用.
- 衰老会影响运动任务期间脊柱反射活动的神经控制.
相关概念视频
Aging
577
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
577
Pharmacodynamics in Geriatric Patients: Effects of Age
180
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
180
Spinal Cord: Cross-sectional Anatomy
4.1K
The cross-sectional anatomy of the spinal cord offers a detailed view of its complex structure and function within the central nervous system. At the core of the spinal cord lies the gray matter, characterized by its butterfly or "H"-shaped appearance in cross-section. This central region is enveloped by white matter, with the overall structure divided into symmetrical halves by the dorsal median sulcus and the ventral median fissure.
Gray Matter and its Components
Central to the gray matter is...
Gray Matter and its Components
Central to the gray matter is...
4.1K
The Effect of Aging on Tissues
3.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.1K


