与肥胖相关的代谢表型,代谢过渡和中国中老年人和老年人的认知功能之间的关联
Qing Ma1, Yuxin Jiao2, Shengzhi Mu3
1Department of Geriatrics, Shaanxi Provincial People's Hospital, Xi'an, Shaanxi, 710068, People's Republic of China.
Journal of multidisciplinary healthcare
|November 14, 2025
概括
代谢健康,而不仅仅是体重,是认知衰老的关键. 保持健康的新陈代谢,即使超重,提高认知功能,并减缓老年人的衰退.
科学领域:
- 老年学是一门学科.
- 代谢健康 代谢健康
- 认知神经科学 认知神经科学
背景情况:
- 肥胖和代谢功能障碍在老年人群中越来越令人担忧.
- 了解代谢状态,体重和认知衰老之间的相互作用对公共健康至关重要.
- 在中国老年人中,对代谢表型和认知轨迹的纵向数据有限.
研究的目的:
- 调查肥胖相关的代谢表型与认知功能改善之间的关联.
- 检查随着时间的推移,新陈代谢状态的转变如何影响认知轨迹.
- 分析这些关系在中国中年和老年人的全国代表性队列中.
主要方法:
- 利用来自中国健康与退休长度研究 (CHARLS) (2011-2020) 的数据.
- 他们将参与者分为四种BMI代谢表型:MHNW,MUNW,MHOO,MUOO.
- 采用考克斯回归模型来评估代谢表型,过渡和认知变化 (情节性记忆,精神状态,整体认知) 之间的关联.
主要成果:
- 代谢健康超重/肥胖 (MHOO) 显示出优越的认知功能和与认知改善的积极关联.
- 代谢不健康的正常体重 (MUNW) 与较差的认知结果和改善的可能性较低有关.
- 稳定的MHOO状态预测了更大的认知改善,而从MHNW过渡到MUNW与认知结果的下降有关.
结论:
- 代谢健康,无论BMI,是认知功能和认知衰老的重要预测因素.
- 优先考虑代谢健康干预措施可能对维持老年人的认知活力至关重要.
- 这些发现强调了代谢状态在认知衰老轨迹中的重要性.
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