认知训练在血管认知障碍中重组了前侧-双侧网络的横向化
Xinhu Jin1,2, Yi Xing3,4,5, Baihan Lyu1,6
1Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.
Brain communications
|November 14, 2025
概括
在无痴呆症的血管性认知障碍 (VCIND) 中的认知训练通过减少前侧-双侧网络横向化,暂时改善了大脑功能和记忆力. 这些福利在六个月内消失了.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 神经学 神经学
背景情况:
- 无痴呆症的血管认知障碍 (VCIND) 涉及来自血管原因的认知缺陷,与痴呆症不同.
- 额头-双脑网络 (FPN) 对受VCIND影响的认知功能和认知训练至关重要.
- 在VCIND中认知训练的机制,特别是关于大脑功能横向化的机制,尚不清楚.
研究的目的:
- 研究皮下VCIND和计算机认知训练对大脑FPN功能横向化的影响.
- 检查FPN横向化和VCIND患者和健康成年人的认知表现之间的关系.
- 评估认知训练对FPN横向化和认知功能的短期和长期影响.
主要方法:
- 一个随机的,主动控制的试验,涉及VCIND患者 (n=60) 和一个健康的老年对照组 (n=30).
- 评估FPN的静止状态功能横向化指数 (LI) 和在基线,干预后 (7周) 和6个月后续的神经心理测试.
- 在VCIND患者 (培训和控制组) 和健康的老年人之间比较FPN横向化模式.
主要成果:
- 在基线,VCIND患者表现出与健康成年人相似的FPN横向化,右侧侧向的LI与健康个体的记忆相关.
- 经过训练后,VCIND组显示FPN侧面化 (双边LI) 减少,向左移动与改善的执行和记忆功能相关.
- 在训练组的认知改善和改变的FPN横向化在6个月的随访中没有持续.
结论:
- 皮下VCIND影响FPN侧面化与认知之间的关联,而不是从根本上改变侧面化模式.
- 短期认知训练通过FPN重组和补偿在VCIND中增强执行和记忆功能.
- 这种类型的训练所带来的认知效益和相关的神经变化可能是短暂的,随着时间的推移而减少.
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