肺癌中的免疫瘤学-微生物组轴:从致癌发生到治疗 - - 一篇叙述性综述
Mengyi Shen1, Yueying Chen1, Jiayan Chen1
1Department of Respiratory and Critical Care Medicine, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
Translational lung cancer research
|November 14, 2025
概括
肺部微生物组影响肺癌的发展和治疗反应. 了解免疫瘤学-微生物组 (IOM) 轴是开发肺癌新型微生物组治疗方法的关键.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 肺部微生物组在肺癌的发病,进展,转移和治疗耐药性方面发挥着关键作用.
- 微生物失生症是肺癌进展的重要风险因素.
- 微生物殖民肺部和瘤,表明在肺癌中起着广泛的作用.
研究的目的:
- 在肺癌中探索免疫瘤学-微生物组 (IOM) 轴.
- 检查各种解剖部位的微生物群落.
- 研究它们与瘤免疫微环境的相互作用以及对免疫疗法的影响.
主要方法:
- 在PubMed和Web of Science的系统文献搜索.
- 包括2014年至2025年间发表的英语文章.
- 使用与肺癌和微生物组相关的关键词.
主要成果:
- 肺癌相关的微生物群包括肠道,下呼吸道和瘤内微生物群.
- 微生物群落调节抗瘤免疫反应和瘤免疫微环境.
- 微生物群可以影响肺癌免疫治疗的有效性.
结论:
- IOM轴涉及免疫细胞,癌细胞和微生物之间的动态相互作用.
- 微生物衍生代谢物显示出作为肺癌生物标志物的潜力.
- 基于微生物组的疗法对肺癌治疗有前途.
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