含有白色玄米精油的纳米口水为口腔卫生的强有力的替代品
Nguyen Phuoc Vinh1,2, Nguyen Vu Giang Bac3, Nguyen Du Thien1
1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, University of Health Sciences, Vietnam National University Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Iranian journal of microbiology
|November 14, 2025
概括
纳米分散增强了口水中的白香精油,具有强大的抗菌作用. 稳定的配方快速杀死突变性链球菌,支持临床开发.
科学领域:
- 自然产品 化学 化学
- 纳米技术纳米技术
- 口腔微生物学 口腔微生物学
背景情况:
- 白色玄米精油 (Ocimum gratissimum) 具有强大的抗菌特性.
- 水性不溶性和高挥发性限制了其在口腔护理产品中的使用.
- 突变性链球菌 (Streptococcus mutans) 是导致牙的关键病原体.
研究的目的:
- 开发一个稳定的纳米分散口水配方的白色玄米精油.
- 优化表面活性剂/辅助表面活性剂系统,以提高油溶性和稳定性.
- 为了评估物理化学性质和抗菌疗效对Streptococcus mutans.
主要方法:
- 配方是使用白色玄米精油,Tween-80,异醇,Labrasol和水准备的.
- 测量了物理化学性质 (粒子大小,泽塔潜力,pH).
- 在加速和压力条件下评估稳定性;通过最小杀菌度 (MBC) 确定抗菌疗效.
主要成果:
- 优化纳米分散的粒子大小为128nm,pH为3.42.
- 在各种储存条件下,该配方在三个月内表现出优异的热力学稳定性.
- 在30秒曝光后,针对Streptococcus mutans的最小杀菌度 (MBC) 是0.4% w/v 精油.
结论:
- 纳米分散是一种可行的策略,可以将白色玄米精油纳入口水中.
- 开发的口水配方是稳定的,并表现出快速的杀菌活性.
- 这种有前途的口腔护理剂需要进一步的临床和商业评估.
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