身体能力在功能障碍中调节肠道屏障功能障碍:纤维肌痛和刺激性肠综合征的表型特异性模式
Francesco Russo1, Antonella Bianco2, Laura Prospero1
1Functional Gastrointestinal Disorders Research Group, National Institute of Gastroenterology IRCCS "Saverio de Bellis", Castellana Grotte, Italy.
身体能力 (PC) 在纤维肌痛 (FM) 和刺激性肠综合征 (IBS) 中显著影响肠道屏障功能. 较高的PC与肠道透性降低有关,这表明PC评估是针对这些慢性重叠疼痛综合征的个性化治疗.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 疼痛医学 医学 疼痛医学
背景情况:
- 肠道屏障功能障碍在纤维肌痛 (FM) 和刺激性肠综合征 (IBS) 中越来越多地被认可.
- 在这些条件下,身体能力 (PC) 在肠道屏障完整性中的作用尚不清楚.
- 同病性FM和IBS可能呈现出明显的肠道功能障碍模式.
研究的目的:
- 在患有FM,IBS或两者患者中调查身体能力和肠道屏障功能之间的关系.
- 探索与临床表型相关的肠道屏障完整性的特定生物标志物.
- 确定PC是否是肠道屏障功能障碍的独立预测因素.
主要方法:
- 在56名患有FM,IBS或共患FM+IBS的患者中进行了横截面研究.
- 使用血清/便佐努林,I-FABP和乳糖/曼尼托尔 (Lac/Man) 试验评估肠道屏障功能.
- 使用全球身体能力得分 (GPCS) 量化PC,并通过FIQ-R和IBS-SSS评估症状.
主要成果:
- FM + IBS 患者表现出最显著的屏障功能障碍 (便中高素,Lac/Man 比率).
- IBS患者增加了I-FABP,表明上皮损伤.
- 较高的PC (GPCS ≥6) 与血清松素水平相反相关,GPCS是血清松素的独立预测因子.
结论:
- 在FM和IBS中,肠道屏障功能障碍表现出表型特定的特征.
- 在这些疾病中,身体能力显著调节肠道屏障完整性.
- 将PC评估整合到临床表型中可能有助于针对慢性重叠疼痛综合征的个性化管理策略.
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