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Updated: Jan 11, 2026

Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence
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Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence

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突变的NPM1调节PDCD4的泛化降解,并促进白血病发生

Chuangxuan Liang1,2, Jing Ke1, Zhenyu Zhang1

  • 1School of Basic Medical Sciences, Hubei University of Medicine, Shiyan, China.

iScience
|November 14, 2025
PubMed
概括

编程细胞死亡4 (PDCD4) 蛋白质错位化和被突变的NPM1 (NPMc+) 降解驱动白血病. 阻断NPMc+/PDCD4相互作用在NPM1-突变急性髓性白血病 (AML) 模型中显示出治疗前景.

关键词:
细胞生物学 细胞生物学分子生物学分子生物学

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