一项多中心的前性队列研究,研究了德国多发性硬化症患者对抗SARS-CoV-2疫苗接种反应
Achim Berthele1, Clemens Gödel2, Boris-Alexander Kallmann3
1Department of Neurology, School of Medicine and Health, Technical University Munich, München, Germany.
Frontiers in neurology
|November 14, 2025
概括
多发性硬化症 (MS) 患者对SARS-CoV-2疫苗表现出幽默性免疫反应,尽管某些疾病修饰疗法 (DMT),如抗CD20和S1PR调节器,影响了反应的持续性.
科学领域:
- 免疫学 免疫学 免疫学
- 神经学 神经学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 流行病学队列研究,调查多发性硬化症 (MS) 患者的临床和血清学数据.
- 专注于在现实世界中对严重呼吸系统综合征冠状病毒-2 (SARS-CoV-2) 疫苗接种周期的免疫反应.
研究的目的:
- 在SARS-CoV-2疫苗接种期间记录MS患者的临床和血清学数据.
- 在疫苗接种周期中调查对授权SARS-CoV-2疫苗的幽默免疫反应.
- 评估免疫反应的持续性,并确定影响其因素,包括疾病修饰疗法 (DMT).
主要方法:
- 成年多发性硬化症患者在26个月内被纳入,包括那些计划,接受或最近完成SARS-CoV-2疫苗接种的人.
- 幽默免疫反应 (抗SARS-CoV-2尖端蛋白IgG和中和抗体[NAb]) 在基线,~1个月和~6个月的接种后被测量.
- 通过IgG标位增加和NAb血清阳性定义的免疫反应;随着时间的推移评估持久性.
主要成果:
- 大约1个月后,68.1%的人显示IgG增加,72.1%的NAb血清阳性.
- 免疫反应在6个月后在71.8% (IgG) 和93.7% (NAb) 的最初响应者中持续存在.
- 与其他DMT或没有DMT相比,在服用抗CD20或S1PR调节剂的患者中观察到减少的反应和持续性;36.5%的患者经历了突破性感染.
结论:
- 大多数DMT没有影响对SARS-CoV-2疫苗的幽默反应,除了抗CD20抗体和S1PR调节器.
- 在大多数最初响应者中,幽默性免疫反应持续至少3个月.
- 在抗CD20抗体/S1PR调节器子组中,响应持久性下降.
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