治疗后的肺结核后果:一种廉价的临床实验室诺莫图,用于预测组织破坏
Min Xu1, Jiahui He2, Jianju Feng3
1Department of Respiratory and Critical Care Medicine, Zhuji People's Hospital of Zhejiang Province, Zhuji Affiliated Hospital of Wenzhou Medical University, Zhuji, Zhejiang 311800, China.
一种新型的诺米图准确地预测了结核病 (TB) 幸存者的肺部破坏 (LD),使用了常规的临床和实验室数据. 这种工具有助于为结核病患者提供个性化的随访和干预措施,改善生活质量.
科学领域:
- 肺部医学 肺部医学
- 放射学 放射学是一门学科.
- 临床诊断 临床诊断 临床诊断
背景情况:
- 治疗后的肺部破坏 (LD) 对肺结核 (TB) 幸存者的生活质量产生了负面影响.
- 目前用于LD早期风险分层的工具是不够的.
研究的目的:
- 开发和内部验证用于预测标准抗结核病治疗结束时LD的临床实验室名谱.
主要方法:
- 分析了205名尚未接受过治疗的肺结核病患者的回顾性队列.
- 最小绝对收缩和选择运算符 (LASSO) 和逐步后勤回归确定了预测因素.
- 模型性能与随机森林 (RF) 和支持矢量机 (SVM) 分类器进行了比较,并通过引导重新抽样进行了内部验证.
主要成果:
- 在29.8%的患者中发生了下肢损伤.
- 九种预测因子 (包括病,耐药性,症状到治疗延迟,淋巴细胞计数,CRP,AST,GT,白蛋白,和基线骨质疏通/腔) 的诺图显示出良好的分辨率 (AUC=0.93) 和良好的校准.
- 与全方位治疗或无人治疗策略相比,名图显示出更高的临床效用.
结论:
- 综合常规临床和实验室数据的可访问的诺米图准确地预测结核病患者治疗后的LD.
- 这种工具可以促进个性化后续和及时干预.
- 建议在潜在的多中心队列中进行外部验证.
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