中国东部艾滋病毒感染者的疾病谱和特征:一项为期12年的研究
Ye Xiong1, Bohao Dai1, Dairong Xiang1
1Department of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Mediterranean journal of hematology and infectious diseases
|November 14, 2025
概括
患有人类免疫缺陷病毒 (HIV) 的住院患者从机会性感染转变为恶性瘤,特别是非艾滋病定义的癌症. 早期诊断和最佳管理对于改善艾滋病毒感染者的治疗结果至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 获得性免疫缺陷综合征 (艾滋病) 仍然是一个重大的全球健康挑战.
- 艾滋病毒感染者 (PWH) 的住院治疗往往是由于机会性感染和恶性瘤.
- 了解PWH疾病发展模式对于有效的医疗保健策略至关重要.
研究的目的:
- 在12年的时间里,分析艾滋病毒感染者住院患者 (PWH) 疾病呈现的变化趋势.
- 为了识别导致PWH住院的疾病频谱中的变化.
- 为了解中国东部艾滋病毒护理的不断发展的临床环境提供见解.
主要方法:
- 从2010年1月至2021年12月,对2,140名住院的PWH进行了回顾性分析.
- 收集和评估人口统计,临床和实验室数据.
- 对机会性感染,恶性瘤和住院结局的评估.
主要成果:
- 机会性感染的减少与恶性瘤的增加形成对比,特别是非艾滋病定义癌症 (NADCs).
- 到2020-2021年,NADC的发病率超过了机会性感染,这表明疾病频谱发生了重大转变.
- 随着时间的推移,整体住院死亡率下降,机会性感染,恶性瘤和CD4+T细胞计数作为独立预测因素.
结论:
- 过去12年来,艾滋病毒感染者的疾病谱显著发展.
- 早期的艾滋病毒诊断和获得最佳治疗对于管理PWH至关重要.
- 这项研究强调了适应性医疗保健战略的必要性,以应对不断变化的与艾滋病毒有关的健康问题.
相关概念视频
Retrovirus Life Cycles
49.2K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
49.2K
Sexually Transmitted Infections
892
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
892
Immunodeficiency Diseases
1.9K
Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...
There are three main causes of immunodeficiency...
1.9K
Pulmonary Tuberculosis I
816
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
816
Single Nucleotide Polymorphisms-SNPs
17.9K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
17.9K


