综合的饮食模式通过遗传和代谢机制解释了通过遗传和代谢机制获得的囊性病风险
Chenhao Xu1, Junjie Zhao1, Kan Wu1
1Department of Urology, Institute of Urology, Sichuan Clinical Research Center for Kidney and Urologic Diseases, West China Hospital, Sichuan University, Chengdu, China.
Frontiers in nutrition
|November 14, 2025
概括
饮食模式影响获得性囊 (ARC) 风险. 高脂肪和高糖饮食增加了ARC,而富含微量营养素的饮食提供了保护. 了解这些饮食模式对于脏健康至关重要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 营养流行病学 营养流行病学
- 代谢学 代谢学 代谢学
背景情况:
- 获得性囊 (ARC) 与功能下降有关.
- 在大群体中需要新的饮食模式 (DP) 分析,以了解ARC的发展.
- 饮食因素可能在ARC的病因学中发挥重要作用.
研究的目的:
- 调查综合饮食模式与获得性囊 (ARC) 风险之间的关联.
- 确定有助于ARC发展的特定饮食成分.
- 探索代谢物在饮食与ARC关系中的潜在调解作用.
主要方法:
- 英国生物银行前性队列研究 (2006-2010) 超过119,000名参与者.
- 综合饮食模式整合 (CDPI) 使用降低等级回归 (RRR) 和隐性配置分析 (LPA).
- 考克斯回归分析用于ARC风险评估和NMR代谢物分析用于调解.
主要成果:
- 在10.57年的中位数随访期间,发现了850例获得性囊 (ARC).
- 富含脂质和高血糖饮食模式与ARC风险增加有关 (例如,HRs>1.08).
- 富含微量营养素的饮食模式显示出对ARC的保护作用较弱 (例如,HR<0.95).
结论:
- 富含脂肪 (奶酪,黄油,披萨) 和糖 (巧克力,含糖饮料) 的饮食增加了ARC风险.
- 富含微量营养素和纤维 (蔬菜,水果,瘦肉家禽,坚果,蛋) 的饮食有助于预防ARC.
- 分支链氨基酸,IGF-1和红细胞分布宽度被确定为关键的调解因素.
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