Jove
Visualize
联系我们

相关概念视频

Liver Regeneration01:24

Liver Regeneration

4.2K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.2K
The Tumor Microenvironment02:17

The Tumor Microenvironment

7.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.6K
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow01:26

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

208
Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
208
Introduction to Fibroblasts01:09

Introduction to Fibroblasts

3.8K
Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
3.8K
Liver Histology01:27

Liver Histology

4.0K
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
4.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

<i>Rabdosia rubescens</i> Inhibits CYP7A1 Expression and Induces Autophagy to Reduce Alcohol-Induced Liver Damage in Mice.

Canadian journal of gastroenterology & hepatology·2025
Same author

Extensive Review of Nanomedicine Strategies Targeting the Tumor Microenvironment in PDAC.

International journal of nanomedicine·2025
Same author

Regulation of Mitochondrial Function by Natural Products for the Treatment of Metabolic Associated Fatty Liver Disease.

Canadian journal of gastroenterology & hepatology·2021
Same author

Nonalcoholic Fatty Liver Disease: Pathogenesis and Treatment in Traditional Chinese Medicine and Western Medicine.

Evidence-based complementary and alternative medicine : eCAM·2020
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关实验视频

Updated: Jan 11, 2026

A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties
08:40

A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties

Published on: August 7, 2020

6.7K

肝纤维化:细胞与微环境之间的相互作用

Xi Zou1, Yunling Ke1, Yidan Shao1

  • 1Department of Pharmaceutical Preparation, The Hangzhou Xixi Hospital Affiliated to Zhejiang Chinese Medical University, Zhejiang, China.

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
|November 14, 2025
PubMed
概括

肝硬化前体的肝纤维化,涉及肝损伤激活免疫细胞和肝星细胞 (HSCs) 存储多余的细胞外基质 (ECM). 了解这些机制对于开发有效的肝纤维化治疗至关重要.

关键词:
细胞外矩阵刚度 细胞外矩阵刚度肝脏的星形细胞.肝脏纤维化 肝脏纤维化

更多相关视频

3D Imaging of the Liver Extracellular Matrix in a Mouse Model of Non-Alcoholic Steatohepatitis
06:46

3D Imaging of the Liver Extracellular Matrix in a Mouse Model of Non-Alcoholic Steatohepatitis

Published on: February 25, 2022

2.3K
Long Term Intravital Multiphoton Microscopy Imaging of Immune Cells in Healthy and Diseased Liver Using CXCR6.Gfp Reporter Mice
11:44

Long Term Intravital Multiphoton Microscopy Imaging of Immune Cells in Healthy and Diseased Liver Using CXCR6.Gfp Reporter Mice

Published on: March 24, 2015

12.5K

相关实验视频

Last Updated: Jan 11, 2026

A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties
08:40

A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties

Published on: August 7, 2020

6.7K
3D Imaging of the Liver Extracellular Matrix in a Mouse Model of Non-Alcoholic Steatohepatitis
06:46

3D Imaging of the Liver Extracellular Matrix in a Mouse Model of Non-Alcoholic Steatohepatitis

Published on: February 25, 2022

2.3K
Long Term Intravital Multiphoton Microscopy Imaging of Immune Cells in Healthy and Diseased Liver Using CXCR6.Gfp Reporter Mice
11:44

Long Term Intravital Multiphoton Microscopy Imaging of Immune Cells in Healthy and Diseased Liver Using CXCR6.Gfp Reporter Mice

Published on: March 24, 2015

12.5K

科学领域:

  • 肝病学 肝病学是一种肝病学.
  • 细胞生物学 细胞生物学
  • 病理学 病理学 病理学

背景情况:

  • 肝纤维化是慢性肝病向肝硬化进展的关键中间阶段.
  • 脱补偿性肝病与快速增加的死亡率有关.

研究的目的:

  • 探索肝纤维化背后的机制.
  • 审查肝纤维化中的细胞和微环境变化.
  • 为肝纤维化的临床治疗策略提供见解.

主要方法:

  • 对有关肝纤维化机制的现有文献的审查.
  • 分析细胞相互作用和微环境变化.
  • 纤维化特征的总结.

主要成果:

  • 肝损伤引发炎症并激活肝星细胞 (HSC).
  • 激活的HSCs分泌出过多的细胞外基质 (ECM),导致纤维化.
  • 改变的肝脏微环境使HSC激活和纤维化进展延续.

结论:

  • 肝纤维化是一个复杂的过程,由细胞激活和微环境变化驱动.
  • 了解这些机制是开发向治疗的关键.
  • 进一步的研究可以为改善肝纤维化的临床治疗提供信息.