阿尔茨海默病中的侧面化干扰和动态平衡改变:对半球相互作用和认知表现的影响
Juan Wang1, Yuxin Li1, Yu Yang1
1School of Electrical Engineering, Yanshan University, Qinhuangdao, China.
Human brain mapping
|November 14, 2025
概括
阿尔茨海默病 (AD) 扰乱了大脑的侧向,显示左侧较少,右侧较多,特别是在关键网络中. 这种大脑横向性的不平衡与认知能力下降有关.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 医疗成像医学成像
背景情况:
- 大脑侧面化或功能专业化对于自适应性认知功能至关重要.
- 异常横向化与神经系统疾病有关,但在阿尔茨海默氏症 (AD) 中的动态尚不清楚.
研究的目的:
- 为了研究与健康对照组 (HC) 相比,阿尔茨海默病 (AD) 患者的大脑横向性的动态变化.
- 探索大脑侧面性变化和AD认知障碍之间的关系.
主要方法:
- 利用了来自109名参与者的静止状态fMRI数据 (49名AD,60名HC).
- 使用移动窗口分析计算动态横向性指数 (DLI) 来评估横向性逆转 (LR) 和横向性波动 (LF).
- 采用统计分析来比较群体和斯皮尔曼相关性来将横向度量与认知表现联系起来.
主要成果:
- 艾滋病患者的左侧化减少,右侧化增加,特别是在体运动网络 (SMN) 和默认模式网络 (DMN) 中.
- 在AD中观察到LR降低和LF增加,表明半球内和半球间通信中断.
- 这些动态横向化异常与高阶认知网络的认知障碍和更高的脆弱性有关.
结论:
- 阿尔茨海默氏症的特点是大脑侧面化的动态平衡受损,特别是在高阶皮质网络中.
- 动态横向性指标的异常可能导致AD中观察到的病理生理学和认知缺陷.
- 这些发现凸显了动态横向化变化对于理解AD进展的重要性.
相关概念视频
Lateralization
949
Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.
949
Cerebral Hemispheres
2.0K
The human brain, a complex organ, is functionally divided into two cerebral hemispheres—left and right. These hemispheres are interconnected by a structure of paramount importance, the corpus callosum. This substantial bundle of neural fibers is not just a bridge between the hemispheres but a crucial element for the brain's comprehensive functioning. It enables efficient communication between the two hemispheres, allowing each side of the brain to control and receive sensory and motor...
2.0K
Alzheimer's Disease: Overview
1.6K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.6K
Role of Hippocampus in Memory
1.4K
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
1.4K
Role of Cerebellum and Prefrontal Cortex in Memory
996
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
996


